Brain and Genetic Predictors of Individual Differences in Pain and Analgesia

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

541 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-11-07

Study Completion Date

2023-10-01

Brief Summary

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The purpose of the study is to gain a better understanding of pain processing in the brain. Our understanding of how pain is processed in the brain is limited. We are testing for individual differences in pain perception and emotion.

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Detailed Description

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Conditions

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Pain, Acute

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Single group

All participants are administered Control and Placebo creams (two interventions), with thermal and mechanical painful stimuli delivered repeatedly after each intervention. The order of intervention testing is Control, Placebo, Placebo, Control in a fixed order. All interventions are completed within a single testing session.

Placebo Cream

Intervention Type BEHAVIORAL

In the Placebo intervention, participants are given an inert cream with instructions that it is "Prodicaine, an effective pain-relieving drug". The cream is applied to two fingers on the left hand.

Control Cream

Intervention Type BEHAVIORAL

In the Control intervention, participants are given an inert cream with instructions that it is "a control cream with no effects" . The cream is applied to two fingers on the left hand.

Interventions

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Placebo Cream

In the Placebo intervention, participants are given an inert cream with instructions that it is "Prodicaine, an effective pain-relieving drug". The cream is applied to two fingers on the left hand.

Intervention Type BEHAVIORAL

Control Cream

In the Control intervention, participants are given an inert cream with instructions that it is "a control cream with no effects" . The cream is applied to two fingers on the left hand.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Participants must be registered in the Colorado Community Twin Sample (CTS).

Exclusion Criteria

* Not being registered in the Colorado Community Twin Sample (CTS).
* Any MRI contraindications.

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Tor Wager

Director, Cognitive and Affective Neuroscience Laboratory; Professor, Department of Psychology and Neuroscience and the Institute for Cognitive Science

Responsibility Role PRINCIPAL_INVESTIGATOR