Investigating the Role of Brain-derived Neurotrophic Factor (BDNF) Between Pain and Other Neuronal Disease

NCT ID: NCT03606915

Last Updated: 2020-02-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

131 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-07-10

Study Completion Date

2019-12-31

Brief Summary

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Measure the cytokines, transforming or neurotrophic factors in CSF and plasma as the pain markers and as a new therapeutic target for pain control.

Detailed Description

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The research protocol was approved by the Institutional Review Board (IRB) for the Protection of Human Subjects at National Cheng Kung University Hospital (NCKUH/B-ER-104-070). The study procedures were performed according to the rules of IRB and fully explained to the participants. Blood and CSF samples were collected and compared the difference in no pain group, acute pain group, and chronic pain group.

Conditions

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Pain

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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no pain

pain evaluation for patients performed surgery without painful condition (bleeding or others)

pain evaluation

Intervention Type BEHAVIORAL

collect CSF during spinal anesthesia

acute pain

pain evaluation for patients performed surgery with painful condition within several days

pain evaluation

Intervention Type BEHAVIORAL

collect CSF during spinal anesthesia

chronic pain

pain evaluation for patients performed surgery with the painful condition for over months

pain evaluation

Intervention Type BEHAVIORAL

collect CSF during spinal anesthesia

Interventions

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pain evaluation

collect CSF during spinal anesthesia

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* . Patients undergo spinal anesthesia
* . Over 20 years of age

* Patients who are competent to understand the study and provide written informed consent.

Exclusion Criteria

* Patients have the contraindication for spinal anesthesia (refuse spinal anesthesia, coagulopathy, severe aortic stenosis)
* Refuse participated in this study or pre-existent neurological disease.
* Patients with advanced tumor staging (stage 3 or 4).
Minimum Eligible Age

20 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cheng-Kung University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yen Chin Liu

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yen-Chin Liu, MD PhD

Role: PRINCIPAL_INVESTIGATOR

National Cheng Kung University

Locations

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National Cheng Kung University

Tainan City, , Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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B-ER-104-070

Identifier Type: -

Identifier Source: org_study_id

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