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Differences in Brain Derived Neurotrophic Factor Levels Between Chronic and Asymptomatic Pain Patients

NCT ID: NCT05736575

Last Updated: 2023-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

66 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-15

Study Completion Date

2024-12-30

Brief Summary

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A case-control study will be conducted to analyze the differences in BDNF levels between patients with chronic pain and asymptomatic people.

Detailed Description

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Brain-derived neurotrophic factor (BDNF) is considered a biomarker of brain plasticity. Since different alterations in brain plasticity have been found in chronic pain patients, the investigators want to study whether there are differences at the molecular level in this population compared to an asymptomatic population in order to be able to accurately measure the impact of different physiotherapy interventions in an objective way.

Conditions

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Chronic Pain

Keywords

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BDNF

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Chronic Pain Patient

A blood draw is to be performed to analyze peripheral BDNF.

BDNF analysis (Elisa KIT)

Intervention Type GENETIC

Analysis of peripheral BDNF will be performed

Asymptomatic subject

A blood draw is to be performed to analyze peripheral BDNF.

BDNF analysis (Elisa KIT)

Intervention Type GENETIC

Analysis of peripheral BDNF will be performed

Interventions

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BDNF analysis (Elisa KIT)

Analysis of peripheral BDNF will be performed

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* males and females aged 18 to 65 years with musculoskeletal pain for a minimum of 3 months
* patients recruited by information pamphlets from the university clinic of the Rey Juan Carlos University, and CSEU La Salle
* not having received physiotherapy treatment for this same process in the last 3 months.
* ability to perform all the clinical tests and to understand the study process, as well as to obtain informed consent.

Exclusion Criteria

* Systemic, neurological, oncological or inflammatory diseases; psychiatric pathologies, pregnancy, type II diabetes.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universidad Rey Juan Carlos

OTHER

Sponsor Role collaborator

Universidad Autonoma de Madrid

OTHER

Sponsor Role lead

Responsible Party

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Raúl Ferrer-Peña

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Irf Cseuls

Madrid, , Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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Raúl Ferrer, PhD

Role: CONTACT

Phone: +34655412476

Email: [email protected]

Facility Contacts

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Raul Ferrer, Physical Therapist

Role: primary

Other Identifiers

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CCBDNF

Identifier Type: -

Identifier Source: org_study_id