Effects of Anticipation of Pain Relief on Brain Mechanisms
NCT ID: NCT00200876
Last Updated: 2017-03-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2003-09-30
2008-06-30
Brief Summary
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Detailed Description
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This study will last several hours during one study visit. Participants will receive both a painful and a painless injection while undergoing positron emission tomography (PET) brain imaging. The painful injection will consist of small amounts of hypertoninc saline (concentrated saline that causes cell shrinkage) in the jaw muscle over a 20-minute period. Several minutes after participants receive hypertonic saline, they will receive an injection with isotonic saline not associated with pain in the opposite jaw muscle. After participants receive the injections, they will either be told or not be told about a pain relief intervention. PET imaging will continue as participants either anticipate or do not anticipate pain relief. Participants will be asked about their pain levels repeatedly throughout the study; their responses will be entered into a computer-controlled system which will modulate rates of saline infusion.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
DIAGNOSTIC
TRIPLE
Study Groups
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pain challenge
Hypertonic saline
To elicit pain
Isotonic saline
Non-painful control
non-painful control
Hypertonic saline
To elicit pain
Isotonic saline
Non-painful control
Interventions
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Hypertonic saline
To elicit pain
Isotonic saline
Non-painful control
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Personal or first-degree (e.g., mother, father, sister, brother) family history of neurologic or psychiatric disorders
* History of substance abuse or dependence
* Left-handed or ambidextrous
* Positive urine toxicology screen
* Acute or uncorrected medical illness that may interfere with the study
* Unable to tolerate brain scanning procedures
* Current treatment with antipsychotics, mood stabilizers, isoniazid (a drug for tuberculosis \[TB\]), glucocorticoids/mineralocorticoids, psychostimulant appetite suppressants, or centrally active antihypertensive drugs
* Treatment with hormones, antidepressants, or opioids within 6 months prior to study entry
* Treatment with sedative hypnotic medications or over-the-counter sleeping aids within 1 month prior to study entry
* Diagnosis of depression
* Competitive exercise, or exercise exceeding 1 hour each day
* Regular smoking within 5 years prior to study entry
20 Years
30 Years
ALL
Yes
Sponsors
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National Center for Complementary and Integrative Health (NCCIH)
NIH
University of Michigan
OTHER
Responsible Party
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Jon-Kar Zubieta
Professor
Principal Investigators
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Jon-Kar Zubieta, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Michigan
Locations
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University of Michigan Medical Center
Ann Arbor, Michigan, United States
Countries
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Other Identifiers
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