Brain, Psychological and Epigenetic Determinants for Optimizing the Treatment of Chronic Low Back Pain

NCT ID: NCT05963451

Last Updated: 2023-09-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-09-07

Study Completion Date

2027-07-16

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this observational study is to better understand the role of the brain in chronic low back pain patients.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Chronic pain affects millions of people worldwide, and the main cardinal sign of any arthritis condition is pain. Several arthritis conditions can cause chronic low back pain (CLBP).The mechanisms that contribute to CLBP are not yet fully understood, but considering the role of the brain in the context of chronic pain, it is only logical to investigate structural and functional brain properties in CLBP, in order to improve diagnosis and treatment of this condition.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Chronic Low-back Pain

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Chronic Low Back Pain (CLBP) group

Participants who will took part in our study are people living with CLBP who will undergo facet thermal ablation treatment

No intervention

Intervention Type OTHER

No intervention will be given in our study since, the investigators are recruiting people who will receive already a facet thermal ablation.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

No intervention

No intervention will be given in our study since, the investigators are recruiting people who will receive already a facet thermal ablation.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Low back pain (≥ 6 months) with or without pain radiating to the legs or radiating to the neck
* Positive medial branch blocks, suggesting that the pain originates from the lumbar facet joints
* Average pain intensity of ≥ 3/10 in the 24-hour period before the initial visit
* Pain primarily localized in the lower back

Exclusion Criteria

* Inadequate pain relief or relief of less than three months following selective thermoablation of medial lumbar branches by radiofrequency
* Neurological, cardiovascular, or pulmonary disorders
* Comorbid pain syndrome
* History of surgical intervention in the back
* A corticosteroid infiltration within the past year
* Pregnancy (current or planned during the course of the study)
* Contra-indication to Magnetic Resonance Imaging (MRI)
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Université de Sherbrooke

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS)

Sherbrooke, Quebec, Canada

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Canada

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Pascal Tétreault, PhD

Role: CONTACT

819-346-1110 ext. 12858

Marylie Martel, PhD

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Pascal Tétreault, PhD

Role: primary

+1 819 821-8000 ext. 74502

Marylie Martel, PhD

Role: backup

+1 819 346-1110 ext. 12858

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2022-4293

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Decoding Chronic Pain With fMRI
NCT01766973 COMPLETED
Episodic Memory Integration and Interference
NCT05974371 NOT_YET_RECRUITING NA