Muscle Damage and Disuse Atrophy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-01

Study Completion Date

2019-10-31

Brief Summary

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Limb injury generally requires a period of recovery during which time the limb is often immobilised (e.g. with a cast or brace) resulting in a rapid loss of skeletal muscle. Despite the importance of muscle loss during injury, our understanding of how it occurs is incomplete. Several factors are likely to contribute, including a lack of muscle contraction and injury induced inflammation. In this study, the investigators will recruit healthy volunteers who will spend 7 days in a knee brace to replicate leg immobilisation. Prior to immobilisation, half of the participants will perform a single session of strenuous resistance exercise which is known to cause muscle damage and initiate an inflammatory response. This is designed to replicate the muscle damage and inflammation that occurs with injury. The remaining half of participants will not perform this exercise, allowing us to look at the additive effect of muscle damage and inflammation on muscle loss with immobilisation.

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Detailed Description

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Conditions

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Muscle Disuse Atrophy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Control

Immobilisation without prior exercise

Group Type NO_INTERVENTION

No interventions assigned to this group

Muscle damage

300 bilateral knee extensor eccentric contraction performed immediately prior to immobilisation

Group Type EXPERIMENTAL

Eccentric exercise

Intervention Type PROCEDURE

300 eccentric contractions of the knee extensors

Interventions

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Eccentric exercise

300 eccentric contractions of the knee extensors

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Aged 18 - 40
* BMI between 18 and 27
* Healthy, recreationally active, non smoker

Exclusion Criteria

* Non-removable metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws) or claustrophobia
* Use of nutritional supplements
* Chronic use of over the counter medication
* Any diagnosed metabolic disease (e.g. type 1 or 2 Diabetes).
* Any diagnosed cardiovascular disease or hypertension.
* Anyone with previous motor disorders. Anyone with a current musculoskeletal injury that may impair their use of crutches.

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes