Optimisation of Eccentric Exercises

NCT ID: NCT06193824

Last Updated: 2024-01-11

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-05-04
• Study Completion Date: 2024-12-31

Brief Summary

Regular physical activity is an important public health lever and is recognised as an alternative in the management of certain long-term conditions. To achieve beneficial effects on the body, exercise recommendations are based on several parameters such as duration, intensity and continuous or intermittent nature of the activity. However, the mode of muscle contraction during exercise is generally little considered or poorly defined in these recommendations, which can lead to prescribing errors. In particular, the eccentric contraction modality, which can be found in actions designed to slow down movement (e.g. walking downhill), represents an interesting strategy, but its prescription modalities are still poorly understood.

The beneficial effects of physical activity are based in part on the release of molecules (myokines) by the skeletal muscles during exercise, which improve the functioning of the body. However, the effect of downhill walking on the release of myokines by the muscle has been little studied. The lack of knowledge of this effect is therefore an obstacle to the use of this exercise modality to try to optimise physical activity recommendations for health or performance improvement.

The aim of this study is therefore to better understand how downhill walking (eccentric muscle contraction) affects the production of molecules by muscles (myokines) during exercise.

Detailed Description

After being informed of the aims, nature and possible risks of the study, written informed consent will be obtained from the subjects.

Prior to enrolment, volunteers will undergo a medical evaluation that includes a review of personal and family medical history, any current medications, and a standard physical examination. Compliance with the inclusion/exclusion criteria will be checked during this examination.

After enrolment, subjects will perform a treadmill familiarization session.

Experimental days:

• Subjects will complete a 45-minute walking exercise on a negative gradient treadmill (6 km/h) in a randomised 2-way cross-over design with either a -10% or -20% gradient.
• Blood will be sampled immediately pre-exercise, 1-h and 24-h post-exercise for the analysis of muscle myokines.
• Exercise-induced muscle fatigue in lower limbs will be evaluated using squat and counter-movement jumps immediately before and post-exercise.
• Heart-rate variability will be measured during the eccentric exercise session.
• Thigh muscle volume will be measured immediately before and post-exercise.
• Exercise-induced myalgia at 24-, 48-, 72- and 96h will be assessed using a visual analogue scale.

Conditions

Healthy Control Subjects

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

downhill treadmill walking -10% gradient

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% incline)

Group Type: EXPERIMENTAL

Experimental: downhill treadmill walking at -10% and -20% gradient

Intervention Type: DEVICE

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% or -20% incline)

downhill treadmill walking -20% gradient

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-20% incline)

Group Type: EXPERIMENTAL

Experimental: downhill treadmill walking at -10% and -20% gradient

Intervention Type: DEVICE

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% or -20% incline)

Interventions

Experimental: downhill treadmill walking at -10% and -20% gradient

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% or -20% incline)

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Body Mass Index between 18.5 and 24.9 kg/m² (18.5 ≤ BMI ≤ 24.9)
• Non-smoker
• No treatment (background or at the time of the examination)
• Physical check up considered compatible with study participation (no bones, articular or muscular problems in lower limbs)
• Subjects considered healthy by investigator based on medical questioning and clinical examination
• Affiliation to the French Social Security system
• Person who has read and understood the research-related information, and signed the consent forms

Exclusion Criteria

• Smoking
• Subjects with heart or respiratory failure
• Participants with lower extremity injury in the past three months
• Contraindication to the application of a magnetic field (wearing a pacemaker, presence of prosthetic material or ferromagnetic foreign bodies, presence of cochlear implants or ocular prosthetic material)
• Participant that does not wish to participate (refusal to sign the consent form)
• Patients under guardianship, trusteeship, deprived of liberty or safeguard of justice

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Clermont-Ferrand

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Chu Clermont Ferrand

Clermont-Ferrand, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Lise Laclautre

Role: CONTACT

promo_interne_drci@chu-clermontferrand.fr

334.73.754.963

Fabrice Rannou

Role: CONTACT

fabrice.rannou@uca.fr

Facility Contacts

Lise Laclautre

Role: primary

promo_interne_drci@chu-clermontferrand.fr

Other Identifiers

RBHP 2022 RANNOU

Identifier Type: -

Identifier Source: org_study_id