MedDataX Logo

Eccentric Resistance Training With Blood Flow Restriction on Muscle Function

NCT ID: NCT04977804

Last Updated: 2023-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-30

Study Completion Date

2025-12-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study will determine the effects of adding blood flow restriction to eccentric training to assess whether this increases the improvements of muscle strength and size.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Subjects will be randomly assigned to two groups: an eccentric only resistance training group or an eccentric training plus blood flow restriction group. Subjects will train at a moderately low intensity on a multiple-joint eccentric device. Those in the blood flow restriction will wear blood flow restriction cuffs on their upper thighs to reduce blood flow during the brief protocol. The training session will occur twice per week and will last \~5 minutes, including a one minute warm up, a one minute cool down and a three minute workout phase. The training program will last 7 weeks. Testing will be conducted at baseline (following a one session familiarization), 4 weeks and after the end of the 7 week training period. Assessments will focus on muscle strength, function, and morphology (size).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Blood Flow Restriction

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

resistance training muscle function quadriceps eccentric strength vertical jump muscle quality muscle hypertrophy eccentric training

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Two group, randomized parallel group design.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors
The person assessing the outcome measures will be blinded to the group designation of the subjects.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Eccentric only training

This is the experimental control; where this group will be used as the standard active comparison condition.

Group Type ACTIVE_COMPARATOR

Exercise

Intervention Type OTHER

The interventions are a form or exercise, specifically resistance exercise.

Eccentric plus blood-flow restriction

This is the experimental condition involving the eccentric resistance training with blood flow restriction.

Group Type EXPERIMENTAL

Eccentric plus blood-flow restriction

Intervention Type OTHER

Eccentric plus blood-flow restriction

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Exercise

The interventions are a form or exercise, specifically resistance exercise.

Intervention Type OTHER

Eccentric plus blood-flow restriction

Eccentric plus blood-flow restriction

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 18-30 years of age
* currently engaged in some form of resistance training between 1-3 times per week
* must have been training aerobically, but no more than 3 hours a week for the past six months

Exclusion Criteria

* Must not have had any surgery of the lower limbs within the past 1 year period
* Must not have any neuromuscular disorder (e.g., Muscular dystrophy etc.)
* \< 76 inches tall (in order to fit on the training machine)
* Maximal strength of \< 725 lbs for the eccentric training device
* If any of the subjects are pregnant or plan to be pregnant in the duration of the protocol.

For those randomized to the BFR group, if any of the subject's thighs are too large for the BFR cuffs (greater than 68 cm).
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Utah State University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Brennan Thompson

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Brennan J Thompson, PhD

Role: PRINCIPAL_INVESTIGATOR

Utah State Univeristy

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Utah State Universtiy

Logan, Utah, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

12042b

Identifier Type: -

Identifier Source: org_study_id