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Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training

NCT ID: NCT02142855

Last Updated: 2017-10-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-05-31

Study Completion Date

2017-05-31

Brief Summary

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The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. Secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. This project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.

Detailed Description

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Conditions

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Healthy

Keywords

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volunteers young (18-30 y) older (65-75 y) age groups

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Old Control

Older individuals (65-75 y) with no exercise intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Old Concentric

Older individuals (65-75 y) studied before and after 8 weeks concentric exercise training

Group Type EXPERIMENTAL

Concentric Exercise Training

Intervention Type BEHAVIORAL

8 weeks concentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Old Eccentric

Older individuals (65-75 y) studied before and after 8 weeks eccentric exercise training

Group Type EXPERIMENTAL

Eccentric Exercise Training

Intervention Type BEHAVIORAL

8 weeks eccentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Young Control

Young individuals (18-30 y) with no exercise intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Young Concentric

Young individuals (18-30 y) studied before and after 8 weeks concentric exercise training

Group Type EXPERIMENTAL

Concentric Exercise Training

Intervention Type BEHAVIORAL

8 weeks concentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Young Eccentric

Young individuals (18-30 y) studied before and after 8 weeks eccentric exercise training

Group Type EXPERIMENTAL

Eccentric Exercise Training

Intervention Type BEHAVIORAL

8 weeks eccentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Interventions

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Concentric Exercise Training

8 weeks concentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Intervention Type BEHAVIORAL

Eccentric Exercise Training

8 weeks eccentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Healthy male volunteers
* Body mass index 18-30 kg/m2
* Aged 18-35 and 65-75 years

Exclusion Criteria

* Participation in a formal exercise regime,
* A BMI \< 18 or \> 30 kg/m2,
* Active cardiovascular disease,
* Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs,
* Cerebrovascular disease,
* Respiratory disease,
* Metabolic disease,
* Active inflammatory bowel or renal disease,
* Malignancy,
* Recent steroid treatment (within 6 months) or hormone replacement therapy,
* Clotting dysfunction,
* Musculoskeletal or neurological disorders,
* Family history of early (\<55y) death from cardiovascular disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Biotechnology and Biological Sciences Research Council

OTHER

Sponsor Role collaborator

University of Nottingham

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marco V Narici, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Nottingham

Locations

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University of Nottingham

Derby, Derbyshire, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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B13032014 SoMSGEM BBSRC3

Identifier Type: -

Identifier Source: org_study_id