Muscle Vibration as a Countermeasure Against Hypoactivity-induced

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-16

Study Completion Date

2027-08-31

Brief Summary

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Muscle deconditioning, characterized by a loss of muscle mass and strength, is a frequent consequence of prolonged lower limb unloading. Beyond muscle mass loss, reduced neural drive contributes significantly to strength decline, highlighting the need for interventions targeting neuromuscular function during immobilization. Focal muscle vibration (FMV) has shown promise in modulating neuromuscular excitability by activating muscle spindle afferents and inducing cortical adaptations. Chronic use of FMV has been associated with significant strength gains and improved neural command. This makes FMV an effective rehabilitation tool. Its simplicity and non-invasiveness further make it a practical countermeasure.

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Detailed Description

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This study hypothesizes that a 10-day FMV protocol can induce neural adaptations to limit strength loss during unilateral lower limb suspension, offering a novel strategy against neuromuscular function decline.

Conditions

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Vibration Therapy Healthy Volunteer Study Hypoactivity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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VIBRATION

Participants will benefit a local vibration countermeasure program for the knee extensor muscles.

Group Type ACTIVE_COMPARATOR

Focal muscle vibration

Intervention Type DEVICE

focal muscle vibration sessions, using small and portable vibrator devices.

CONTROLE

the control group WILL not receive this countermeasure.

Group Type SHAM_COMPARATOR

NO Focal muscle vibration

Intervention Type DEVICE

The control group will not receive any intervention.

Interventions

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Focal muscle vibration

focal muscle vibration sessions, using small and portable vibrator devices.

Intervention Type DEVICE

NO Focal muscle vibration

The control group will not receive any intervention.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Men and women.
* Aged 18 to 45 years.
* Body Mass Index (BMI) between 20 and 25 kg/m².
* Engaging in at least 1.5 hours per week of physical activity (e.g., brisk walking, running, swimming, cycling).
* Provided informed consent after receiving detailed information about the study.
* Affiliated with or beneficiaries of a social security system

Exclusion Criteria

* Chronic cardiovascular, neuromuscular, bone, metabolic, and/or inflammatory disorders.
* Personal history and/or risk factors for thrombosis.
* Use of antidepressant medications.
* Use of neuroactive substances likely to alter corticospinal excitability (e.g., hypnotics, antiepileptics, psychotropics, muscle relaxants) during the study.
* Recent bone or ligament trauma within the past 12 months.
* Inability to perform the physical efforts required for the study.
* Recent participation in a sporting competition or intense, unusual physical activity within the past month.
* Corticosteroid treatment within the past 3 months.
* Any skin lesions at the planned vibrator application site.
* Simultaneous participation in another interventional medical study.
* Pregnant or breastfeeding women.
* Individuals unable to understand the purpose and conditions of the study or unable to provide informed consent.
* Individuals deprived of liberty or under guardianship

Minimum Eligible Age

19 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes