Regional Distribution of Ventilation to Assess Respiratory Muscle Dysfunction

NCT ID: NCT01569217

Last Updated: 2017-05-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-06-30

Study Completion Date

2018-07-31

Brief Summary

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The aim of this study is to better discriminate respiratory muscle dysfunction by comparing the measurements of thoracoabdominal motion obtained by an optoelectronic recording and the conventional tests of respiratory muscle strength. The final objective is to better select in the future the patients who need more specific assessment of diaphragmatic function like "maximal transdiaphragmatic pressure" measurement and "phrenic nerve stimulation".

Detailed Description

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All patients which had suspected respiratory muscle dysfunction will have usual exploration of the respiratory muscles according to the clinician prescription. These explorations can include :

* Lung volumes in seating and supine position
* Maximal inspiratory and expiratory pressures
* Maximal sniff pressures

And when diaphragmatic dysfunction is suspected :

* Maximal transdiaphragmatic pressure
* Phrenic nerve conduction

These patients will also beneficiate to the determination of volume variations of the upper rib cage, the lower rib cage and the abdominal compartments by using Opto-electronic plethysmography.

Conditions

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Respiratory Failure Neuromuscular Disorder Diaphragmatic Paralysis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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respiratory muscle dysfunction patients

Neuromuscular patients

No interventions assigned to this group

diaphragmatic dysfunction

patients who present orthopnea, recruitment of accessory muscles, abdominal paradox, respiratory dysfunction or dyssynchronous movement

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* suspicion of respiratory muscle dysfunction
* indication of diaphragm exploration

Exclusion Criteria

* acute respiratory failure
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre d'Investigation Clinique et Technologique 805

OTHER

Sponsor Role lead

Responsible Party

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Lofaso

MD PhD, Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Frédéric Lofaso, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Centre d'Investigation Clinique et Technologique 805

Locations

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Raymond Poincaré Hospital

Garches, , France

Site Status

Countries

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France

Other Identifiers

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11.155 bis

Identifier Type: REGISTRY

Identifier Source: secondary_id

11 003-CCP Ile de France XI

Identifier Type: -

Identifier Source: org_study_id

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