Diaphragmatic Atrophy Related to Mechanical Ventilation
NCT ID: NCT02766946
Last Updated: 2024-04-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
97 participants
INTERVENTIONAL
2013-06-24
2015-12-22
Brief Summary
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The aim of the study is to visualize the evolution of diaphragm thickness by echography during Mechanical Ventilation for patients with septic shock or acute respiratory distress syndrome and to compare with the evolution for patients under non-invasive ventilation and those with spontaneous ventilation. Measurements will be performed at day 1, day 5 and day 10 (if patient still under a mode of ventilation or in the unit).
The evolution of diaphragm thickness will also be compared to pectoralis muscle atrophy, which is not involved in ventilation, in order to assess respective effect of ventilatory inactivity and undernutrition linked to intensive care.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Mechanical Ventilation
Evolution over time of Diaphragmatic and Pectoralis muscle atrophy under Mechanical Ventilation
Interventions :
* Ultrasound of the right diaphragm
* Ultrasound of the pectoral muscle
* Neuromyopathy score
* Respiratory performances
Ultrasound
An ultrasound of the right diaphragm will be performed on day 1, day 3, day 5 and day 10
Ultrasound
An ultrasound of the pectoral muscle will be performed on day 1, day 3, day 5 and day 10
Neuromyopathy score
A neuromyopathy score will be assessed on the extubation day
Respiratory performances
An assessment of the respiratory performances will be done on the extubation day, including higher expiratory pressure, higher inspiratory pressure, and occlusion pressure
Non-invasive Ventilation
Evolution over time of Diaphragmatic and Pectoralis muscle atrophy under Non-invasive Ventilation
Interventions :
* Ultrasound of the right diaphragm
* Ultrasound of the pectoral muscle
* Neuromyopathy score
* Respiratory performances
Ultrasound
An ultrasound of the right diaphragm will be performed on day 1, day 3, day 5 and day 10
Ultrasound
An ultrasound of the pectoral muscle will be performed on day 1, day 3, day 5 and day 10
Neuromyopathy score
A neuromyopathy score will be assessed on the extubation day
Respiratory performances
An assessment of the respiratory performances will be done on the extubation day, including higher expiratory pressure, higher inspiratory pressure, and occlusion pressure
Spontaneous Ventilation
Evolution over time of Diaphragmatic and Pectoralis muscle atrophy under Spontaneous Ventilation
Interventions :
* Ultrasound of the right diaphragm
* Ultrasound of the pectoral muscle
* Neuromyopathy score
* Respiratory performances
Ultrasound
An ultrasound of the right diaphragm will be performed on day 1, day 3, day 5 and day 10
Ultrasound
An ultrasound of the pectoral muscle will be performed on day 1, day 3, day 5 and day 10
Neuromyopathy score
A neuromyopathy score will be assessed on the extubation day
Respiratory performances
An assessment of the respiratory performances will be done on the extubation day, including higher expiratory pressure, higher inspiratory pressure, and occlusion pressure
Interventions
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Ultrasound
An ultrasound of the right diaphragm will be performed on day 1, day 3, day 5 and day 10
Ultrasound
An ultrasound of the pectoral muscle will be performed on day 1, day 3, day 5 and day 10
Neuromyopathy score
A neuromyopathy score will be assessed on the extubation day
Respiratory performances
An assessment of the respiratory performances will be done on the extubation day, including higher expiratory pressure, higher inspiratory pressure, and occlusion pressure
Eligibility Criteria
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Inclusion Criteria
* Group 1 : under Mechanical Ventilation (time of Mechanical Ventilation for at least 5 days)
* Group 2 : under Non-invasive Ventilation
* Group 3 : Spontaneous Ventilation
* Non opposition of patient (Groups 2 and 3) or non-opposition of patient family member (Group 1)
Exclusion Criteria
* Neurologic pathology with motor deficit
* Pregnancy or breast-feeding woman
18 Years
ALL
No
Sponsors
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Centre Hospitalier Saint Joseph Saint Luc de Lyon
OTHER
Responsible Party
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Other Identifiers
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SJSL12013
Identifier Type: -
Identifier Source: org_study_id
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