Respiratory Muscle Dysfunction in Critically Ill Patients
NCT ID: NCT01104857
Last Updated: 2015-06-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
NA
30 participants
INTERVENTIONAL
2010-04-30
2016-04-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The general hypothesis of the present study is that in critically ill mechanically ventilated subjects respiratory muscle dysfunctions results from loss of myosin induced by activation of proteolytic cascades.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effect of Inspiratory Muscle Training on Duration of Mechanical Ventilation Support
NCT01108575
ICU Acquired Neuromyopathy and Diaphragm Function
NCT01968889
DIAPHRAGM STRENGTH AND LUNG VOLUMES
NCT07206459
Electromyography for Diaphragm Effort
NCT03580720
Effects of COVID-19 Infection and Critical Illness on Diaphragm Tissue Characteristics and Movement, Visualized With MRI
NCT04735757
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Diaphragm muscle biopsy
Patients admitted to the ICU meeting severe sepsis / septic shock criteria
diaphragm muscle biopsy
Biopsy is obtained for biochemical analysis
Elective laparotomy
Diaphragm muscle biopsy
Biopsy is obtained for biochemical analysis
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
diaphragm muscle biopsy
Biopsy is obtained for biochemical analysis
Diaphragm muscle biopsy
Biopsy is obtained for biochemical analysis
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Clinical reason for laparotomy
* \> 18 years
Exclusion Criteria
* Medical history of myopathy
* Unintended weight loss before ICU admission
* Pregnancy
* Chronic use of corticosteroids
18 Years
90 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University Medical Center Nijmegen
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Leo Heunks
MD
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Radboud Universtity Nijmegen Medical Centre
Nijmegen, , Netherlands
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
Diam1
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.