MedDataX Logo

Impact of Respiratory Muscle Unloading on Respiratory Muscle Endurance

NCT ID: NCT00415896

Last Updated: 2006-12-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-12-31

Study Completion Date

2007-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study investigates how different degrees of muscular unloading during mechanical ventilation impact endurance of succeeding spontaneous breathing trials

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Liberation from mechanical ventilation in difficult to wean patients is best accomplished by intermittent spontaneous breathing trials (1). Optimal respiratory muscle rest in-between breathing trials however has never been investigated.

Using a crossover design, patients are to be ventilated with complete and partial respiratory muscle unloading for a period of ten hours respectively. Respiratory muscle activity is being monitored by oesophageal balloon technique using a commercially available System (Avea, Viasys, Conshohocken, PA, USA). Time of spontaneous breathing, respiratory- and ABG parameters are being determined to characterize the course of each spontaneous breathing trial.

References

1\. Esteban, A., F. Frutos, M. J. Tobin, I. Alia, J. F. Solsona, I. Valverdu, R. Fernandez, M. A. de la Cal, S. Benito, R. Tomas, and et al. 1995. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med 332(6):345-50.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Chronic Respiratory Failure

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

weaning work of breathing spontaneous breathing trial rapid shallow breathing

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

positive pressure ventilation

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* hypercapnic respiratory failure

Exclusion Criteria

* upper Gi pathology
* renal failure (creatinin \> 2 mg/dl)
* Sepsis or infection
* age \< 18 years
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Krankenhaus Kloster Grafschaft

OTHER

Sponsor Role lead

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Dominic Dellweg, M.D.

Role: PRINCIPAL_INVESTIGATOR

FKKG

Dieter Koehler, M.D., Prof.

Role: STUDY_CHAIR

FKKG

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Kloster Grafschaft

Schmallenberg, Annostr. 1, Germany

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Germany

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Dominic Dellweg, M.D.

Role: CONTACT

Phone: +49 2972 791

Email: [email protected]

Dieter Koehler, M.D. Prof.

Role: CONTACT

Phone: +40 2972 791

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Dominic Dellweg, M.D.

Role: primary

Dieter Koehler, M.D. Prof.

Role: backup

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

FKKG3

Identifier Type: -

Identifier Source: org_study_id