Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
UNKNOWN
Clinical Phase
NA
Total Enrollment
105 participants
Study Classification
INTERVENTIONAL
Study Start Date
2016-02-29
Study Completion Date
2017-05-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Objectives: This study aims to examine the use of low frequency (2Hz), low amplitude (intensity just produce visible muscle contraction), and long duration (2x3 hrs/day) neuromuscular electrical simulation (NMES) in attenuating the effects of muscle atrophy resulted from disuse.
Design and subjects: The study is a randomized, double-blind, controlled, and parallel group study. Subjects with stable chronic obstructive pulmonary disease (COPD) will be included. Intervention: Subjects will be randomized to 3 groups to receive different NMES program over the quadriceps and calf muscles: (i) the proposed NMES program; (ii) conventional NMES program (50Hz, 30 min/day), or sham group for a period of 8 weeks.
Outcome measures:The effectiveness of the NMES will be evaluated by the improvement in muscle cross-sectional area (CSA), muscle performance (muscle strength, muscle shortening velocity and muscle activation testing), functional performance (6 min walk) and subjects' rating of the perceived acceptability of the stimulation protocol.
Data analysis: Baseline characteristics of the intervention and sham groups will be compared using one way ANOVA. Two-way mixed repeated measures analysis of variance will be performed to examine the differences between groups over time for all the outcome variables. The significance level is set at p \< 0.05.
Expected results: The investigators hypothesize that the proposed new paradigm of NMES would be more effective in improving muscle cross-sectional area (CSA), strength, endurance, and exercise tolerance.
Design and subjects: The study is a randomized, double-blind, controlled, and parallel group study. Subjects with stable chronic obstructive pulmonary disease (COPD) will be included. Intervention: Subjects will be randomized to 3 groups to receive different NMES program over the quadriceps and calf muscles: (i) the proposed NMES program; (ii) conventional NMES program (50Hz, 30 min/day), or sham group for a period of 8 weeks.
Outcome measures:The effectiveness of the NMES will be evaluated by the improvement in muscle cross-sectional area (CSA), muscle performance (muscle strength, muscle shortening velocity and muscle activation testing), functional performance (6 min walk) and subjects' rating of the perceived acceptability of the stimulation protocol.
Data analysis: Baseline characteristics of the intervention and sham groups will be compared using one way ANOVA. Two-way mixed repeated measures analysis of variance will be performed to examine the differences between groups over time for all the outcome variables. The significance level is set at p \< 0.05.
Expected results: The investigators hypothesize that the proposed new paradigm of NMES would be more effective in improving muscle cross-sectional area (CSA), strength, endurance, and exercise tolerance.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Neuromuscular Electrical Stimulation (NMES) Preserves Muscle Mass in Intensive Care Unit (ICU)
NCT05287919
Critical Illness
Physical Disability
Muscle Atrophy
COMPLETED
NA
Effects of Neuromuscular Electrical Stimulation as an Adjunct to Exercise Training in Stable Chronic Obstructive Pulmonary Disease (COPD)
NCT01658046
Chronic Obstructive Pulmonary Disease (COPD)
COMPLETED
NA
Does Neuromuscular Electrical Stimulation Benefit the Functional Ability of Elderly Patients With Chronic Obstructive Lung Disease
NCT05838911
Pulmonary Rehabilitation
Chronic Obstructive Lung Disease
Neuromuscular Electrical Stimulation
+1 more
COMPLETED
NA
Effect of NMES on Quadriceps Muscle Strength and Endurance in Patients With COPD
NCT05539547
Chronic Obstructive Pulmonary Disease Moderate
Chronic Obstructive Pulmonary Disease Severe
Acute Exacerbation of COPD
UNKNOWN
EARLY_PHASE1
Effect of Neuromuscular Electrical Stimulation of Lower Limbs on Improving Exercise Self-Efficacy, Dyspnea During Activity and Fatigue in Patients With Chronic Obstructive Pulmonary Disease
NCT06851195
Chronic Obstructive Pulmonary Disease (COPD)
Neuromuscular Electrical Stimulation (NMES)
Exercise Self-Efficacy
+2 more
ENROLLING_BY_INVITATION
NA
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Introduction:
Skeletal muscle responds to the stimulus of mechanical load for growth and maintenance. Prolonged reductions in muscle activity and mechanical loading such as spaceflight, limb immobilization, bedrest, and/or inactivity alter the balance between protein synthesis and degradation, resulting in skeletal muscle atrophy (1-3). This is characterized by a decrease in muscle mass, myofiber cross-sectional area, contractile strength and speed, as well as slow-to-fast fiber type transformation (4,5). Many countermeasures have been reported to attenuate the loss of muscle atrophy and neuromuscular electrical stimulation (NMES) has been frequently used in conditions such as spinal cord injury, immobilization, and muscle disuse post-surgery (6,7). Indeed, a recent Cochrane review on the effectiveness of NMES for muscle weakness in adults with progressive diseases such as COPD, chronic heart failure and cancer indicated that NMES is an effective means of improving muscle weakness (8). The meta-analyses included eleven randomized controlled trial (RCT) studies involving a total of 218 participants. NMES significantly improved quadriceps strength by a Standardised Mean Difference (SMD) of 0.9 (95% confidence interval (CI) 0.33 to 1.46). This is approximately equals to 25 Newton metres (Nm) and should be regarded as clinically significant. Similarly, another recent systematic review also showed NMES is effective in preventing skeletal-muscle weakness in critically ill patients. Eight eligible studies involving 172 patients were included in the analysis. Out of the eight studies, five studies reported an increase in strength or better preservation of strength with NMES, with one study having a large effect size (1.44). Two studies found better preservation of muscle mass with NMES, with small to moderate effect sizes (0.11-0.39) while no significant benefits were found in two other studies (9).
The effectiveness of NMES is dependent upon the clinical condition and is influenced by different stimulation parameters, particularly the stimulation frequency and duration. Traditionally, NMES has been viewed as the application of a transcutaneous electrical current to the neuromuscular junction, aimed to depolarise the motor unit action potential and inducing muscle contraction (10). This electrically induced muscle contraction simulates active muscle strengthening and is based on the principle of muscle training that by appropriate loading, muscle strength will be increased. To achieve this training effect, the stimulation parameters employed normally aimed to produce tetanic contraction with a current density that the subject can maximally tolerated (8,9). However, this currently adopted stimulation protocol (ie. high frequency at or above 50Hz, amplitude at subjects' maximum tolerated limit and short duration (30 min to 1 hr) to counteract muscle atrophy has two main drawbacks. First, it has been well established that mechanical unloading is associated with detrimental changes to the structure and function of skeletal muscles, characterized by reduction in muscle mass, myofiber cross-sectional area, contractile strength and speed, as well as slow-to-fast fiber type transformation (for review, see 11). Thus, the slow twitch muscle fibers are more susceptible to unloading or disuse effect rather than fast twitch muscle fibers. The traditional high frequency stimulation protocol (50 Hz) does not match the motor unit firing pattern of a slow-twitch muscle. Moreover, the high current density would inevitably caused discomfort if not pain to the subjects during the electrical stimulation. The subjects cannot tolerate the electrical stimulation for hours. This is particularly the case if the application is to the subjects with disuse muscle atrophy or subjects with muscle weakness caused by progressive diseases. Very often, the pain tolerance of this group of subjects is generally lower than the normal healthy subjects. Thus, the currently adopted protocol might not necessary render the best possible outcome of NMES for the enhancement of muscle function. The beneficial effects of NMES to counteract muscle atrophy had not been fully utilized. A recent systematic review that examines metabolic and structural changes in lower limb skeletal muscle following neuromuscular electrical stimulation identified only 18 studies. Eight of these studies investigated enzymatic activities, seven studies on muscle fibre composition, and 14 on muscle fibre size. Among these 18 studies, only 9 are RCT studies, and the methodological quality generally was poor. The authors concluded that NMES seems to be able to produce favourable changes in oxidative enzyme activity, skeletal muscle fibre type and skeletal muscle fibre size. In view of the large heterogeneity in NMES protocols, the authors concluded that there was no definite consensus regarding the stimulation frequencies for optimal muscular changes (12), For instance, Theriault et al. (13) had conducted prolonged electrical stimulation to the knee extensor of 8 healthy adults. The electrical stimulation protocol was of 8-week duration for 8 hour per day and 6 days per week. The stimulation parameter was of low frequency (8 Hz) with intensity just being able to produce visible vibration. The results suggested significant improvement in knee extensor performance after 4 week of stimulation. However, the study is not a RCT study and there is control group in the study. On the other hand, one of the RCT studies that investigated the effects of NMES and incorporated high frequency (50Hz) but very low amplitude (without muscle contraction) as the placebo group had incidentally revealed that the placebo produced better effect than the intervention group. The NMES group vs placebo group by a SMD of -0.12 (95% CI: -0.63, 0.39) (8,14). Banerjee and his group has also shown an electrical stimulation protocol with low frequency (4 Hz) yet high amplitude (300mA), 1 hr/day for 6 week can significantly increase the quadriceps strength of healthy sedentary adults and patients with stable chronic heart failure (15, 16). Thus, the findings from basic science and these clinical studies suggested the need for further exploration of more effective NMES stimulation protocol to attenuate muscle atrophy.
Aims and Hypotheses to be Tested:
To address these, the investigators of this proposal have challenged the traditional thought that NMES should be with high frequency and high amplitude. The investigators had tested the hypothesis that low frequency and low amplitude is effective in attenuating muscle atrophy, and investigated the cellular mechanisms associated with muscle unloading. Using the hindlimb suspension animal model, the investigators have previously demonstrated that, during hindlimb suspension, application of low-frequency electrical stimulation at 20 Hz on the soleus muscles with defined timing and pulse parameters partially rescued the loss of satellite cells and improved fiber cross-sectional areas (17). The investigators have further demonstrated that using an electrical stimulation paradigm of frequency: 20 Hz; duration: 3 h, twice daily to eight-week-old male BALB/c mice that were subjected to a 14-day hindlimb unloading (HU). This stimulation paradigm can enhance satellite cell proliferative potential as well as suppress apoptotic cell death in disuse induced muscle atrophy. Morphologically, the hindlimb with electrical stimulation showed significant improvement in muscle mass, cross-sectional area, and peak tetanic force relative to the HU limb (18). Recently, the investigators further investigated the optimum stimulation protocol and demonstrated that among three low frequency protocol, 2, 10 and 20 Hz, stimulation at 2 Hz for 2 × 3 h/day achieved the best effect in attenuating the loss of muscle fiber cross-sectional area and force. This stimulation parameter led to a 1.2-fold increase in satellite cell proliferation, and was effective in rescuing cells from apoptosis (19). With all these encouraging findings from the basic science research, the investigators believe the proposed new paradigm of NMES can be tested on subjects with progressive muscle atrophy. The investigators hypothesis that NMES at 2 Hz for 2 × 3 h/day is effective in attenuating/improving lower limb postural muscle atrophy, namely quadriceps and gastrocnemius and soleus muscle complex.
Plan of Investigation:
Based on the findings in the existing literature on the current adopted NMES stimulation protocol in attenuating muscle atrophy or improving muscle performance in various populations, the investigators hypothesized that the proposed new paradigm of NMES would be more effective in improving muscle cross-sectional area (CSA), strength, endurance, exercise tolerance, and is more acceptable by subjects who needed NMES to attenuating the muscle atrophy with various medical conditions, in particular chronic obstructive pulmonary disease (COPD) patients.
Skeletal muscle responds to the stimulus of mechanical load for growth and maintenance. Prolonged reductions in muscle activity and mechanical loading such as spaceflight, limb immobilization, bedrest, and/or inactivity alter the balance between protein synthesis and degradation, resulting in skeletal muscle atrophy (1-3). This is characterized by a decrease in muscle mass, myofiber cross-sectional area, contractile strength and speed, as well as slow-to-fast fiber type transformation (4,5). Many countermeasures have been reported to attenuate the loss of muscle atrophy and neuromuscular electrical stimulation (NMES) has been frequently used in conditions such as spinal cord injury, immobilization, and muscle disuse post-surgery (6,7). Indeed, a recent Cochrane review on the effectiveness of NMES for muscle weakness in adults with progressive diseases such as COPD, chronic heart failure and cancer indicated that NMES is an effective means of improving muscle weakness (8). The meta-analyses included eleven randomized controlled trial (RCT) studies involving a total of 218 participants. NMES significantly improved quadriceps strength by a Standardised Mean Difference (SMD) of 0.9 (95% confidence interval (CI) 0.33 to 1.46). This is approximately equals to 25 Newton metres (Nm) and should be regarded as clinically significant. Similarly, another recent systematic review also showed NMES is effective in preventing skeletal-muscle weakness in critically ill patients. Eight eligible studies involving 172 patients were included in the analysis. Out of the eight studies, five studies reported an increase in strength or better preservation of strength with NMES, with one study having a large effect size (1.44). Two studies found better preservation of muscle mass with NMES, with small to moderate effect sizes (0.11-0.39) while no significant benefits were found in two other studies (9).
The effectiveness of NMES is dependent upon the clinical condition and is influenced by different stimulation parameters, particularly the stimulation frequency and duration. Traditionally, NMES has been viewed as the application of a transcutaneous electrical current to the neuromuscular junction, aimed to depolarise the motor unit action potential and inducing muscle contraction (10). This electrically induced muscle contraction simulates active muscle strengthening and is based on the principle of muscle training that by appropriate loading, muscle strength will be increased. To achieve this training effect, the stimulation parameters employed normally aimed to produce tetanic contraction with a current density that the subject can maximally tolerated (8,9). However, this currently adopted stimulation protocol (ie. high frequency at or above 50Hz, amplitude at subjects' maximum tolerated limit and short duration (30 min to 1 hr) to counteract muscle atrophy has two main drawbacks. First, it has been well established that mechanical unloading is associated with detrimental changes to the structure and function of skeletal muscles, characterized by reduction in muscle mass, myofiber cross-sectional area, contractile strength and speed, as well as slow-to-fast fiber type transformation (for review, see 11). Thus, the slow twitch muscle fibers are more susceptible to unloading or disuse effect rather than fast twitch muscle fibers. The traditional high frequency stimulation protocol (50 Hz) does not match the motor unit firing pattern of a slow-twitch muscle. Moreover, the high current density would inevitably caused discomfort if not pain to the subjects during the electrical stimulation. The subjects cannot tolerate the electrical stimulation for hours. This is particularly the case if the application is to the subjects with disuse muscle atrophy or subjects with muscle weakness caused by progressive diseases. Very often, the pain tolerance of this group of subjects is generally lower than the normal healthy subjects. Thus, the currently adopted protocol might not necessary render the best possible outcome of NMES for the enhancement of muscle function. The beneficial effects of NMES to counteract muscle atrophy had not been fully utilized. A recent systematic review that examines metabolic and structural changes in lower limb skeletal muscle following neuromuscular electrical stimulation identified only 18 studies. Eight of these studies investigated enzymatic activities, seven studies on muscle fibre composition, and 14 on muscle fibre size. Among these 18 studies, only 9 are RCT studies, and the methodological quality generally was poor. The authors concluded that NMES seems to be able to produce favourable changes in oxidative enzyme activity, skeletal muscle fibre type and skeletal muscle fibre size. In view of the large heterogeneity in NMES protocols, the authors concluded that there was no definite consensus regarding the stimulation frequencies for optimal muscular changes (12), For instance, Theriault et al. (13) had conducted prolonged electrical stimulation to the knee extensor of 8 healthy adults. The electrical stimulation protocol was of 8-week duration for 8 hour per day and 6 days per week. The stimulation parameter was of low frequency (8 Hz) with intensity just being able to produce visible vibration. The results suggested significant improvement in knee extensor performance after 4 week of stimulation. However, the study is not a RCT study and there is control group in the study. On the other hand, one of the RCT studies that investigated the effects of NMES and incorporated high frequency (50Hz) but very low amplitude (without muscle contraction) as the placebo group had incidentally revealed that the placebo produced better effect than the intervention group. The NMES group vs placebo group by a SMD of -0.12 (95% CI: -0.63, 0.39) (8,14). Banerjee and his group has also shown an electrical stimulation protocol with low frequency (4 Hz) yet high amplitude (300mA), 1 hr/day for 6 week can significantly increase the quadriceps strength of healthy sedentary adults and patients with stable chronic heart failure (15, 16). Thus, the findings from basic science and these clinical studies suggested the need for further exploration of more effective NMES stimulation protocol to attenuate muscle atrophy.
Aims and Hypotheses to be Tested:
To address these, the investigators of this proposal have challenged the traditional thought that NMES should be with high frequency and high amplitude. The investigators had tested the hypothesis that low frequency and low amplitude is effective in attenuating muscle atrophy, and investigated the cellular mechanisms associated with muscle unloading. Using the hindlimb suspension animal model, the investigators have previously demonstrated that, during hindlimb suspension, application of low-frequency electrical stimulation at 20 Hz on the soleus muscles with defined timing and pulse parameters partially rescued the loss of satellite cells and improved fiber cross-sectional areas (17). The investigators have further demonstrated that using an electrical stimulation paradigm of frequency: 20 Hz; duration: 3 h, twice daily to eight-week-old male BALB/c mice that were subjected to a 14-day hindlimb unloading (HU). This stimulation paradigm can enhance satellite cell proliferative potential as well as suppress apoptotic cell death in disuse induced muscle atrophy. Morphologically, the hindlimb with electrical stimulation showed significant improvement in muscle mass, cross-sectional area, and peak tetanic force relative to the HU limb (18). Recently, the investigators further investigated the optimum stimulation protocol and demonstrated that among three low frequency protocol, 2, 10 and 20 Hz, stimulation at 2 Hz for 2 × 3 h/day achieved the best effect in attenuating the loss of muscle fiber cross-sectional area and force. This stimulation parameter led to a 1.2-fold increase in satellite cell proliferation, and was effective in rescuing cells from apoptosis (19). With all these encouraging findings from the basic science research, the investigators believe the proposed new paradigm of NMES can be tested on subjects with progressive muscle atrophy. The investigators hypothesis that NMES at 2 Hz for 2 × 3 h/day is effective in attenuating/improving lower limb postural muscle atrophy, namely quadriceps and gastrocnemius and soleus muscle complex.
Plan of Investigation:
Based on the findings in the existing literature on the current adopted NMES stimulation protocol in attenuating muscle atrophy or improving muscle performance in various populations, the investigators hypothesized that the proposed new paradigm of NMES would be more effective in improving muscle cross-sectional area (CSA), strength, endurance, exercise tolerance, and is more acceptable by subjects who needed NMES to attenuating the muscle atrophy with various medical conditions, in particular chronic obstructive pulmonary disease (COPD) patients.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
COPD
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
PREVENTION
Blinding Strategy
DOUBLE
Participants
Outcome Assessors
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
NMES new paradigm
For the NMES new paradigm, A portable electrical stimulator will be used to produce simultaneous stimulation to both the quadriceps and calf muscles. The stimulator delivers a biphasic, asymmetrical square wave at a pulse width of 250 μs and duty cycle 5:10 sec with 2 Hz frequencies of stimulation. To disperse current intensity and enhance the comfort of the stimulation, large rectangular electrodes (80 × 100 mm) will be positioned at the best motor points of the quadriceps and calf muscles. The electrodes will be secured by tight short and sock at the respective positions. The stimulation intensity will be set to just visible muscle contractions. Stimuli will be applied twice a day for 3 h (with a 2 h rest between treatments), 5 days a week for 8 weeks.
Group Type
EXPERIMENTAL
NMES new paradigm
Intervention Type
DEVICE
stimulation frequency: 2 Hz; intensity: low amplitude; duration: 3 hours, 2 times per day for 8 weeks
NMES conventional
For NMES conventional, the experimental protocol will be the conventional electrical stimulation protocol i.e frequency: 50 Hz; intensity: maximum intensity tolerated by the subject; duration: 30 min.
Group Type
ACTIVE_COMPARATOR
NMES conventional
Intervention Type
DEVICE
stimulation frequency: 50 Hz; intensity: maximally tolerated; duration: 30 min per day for 8 weeks
Placebo
For placebo, electrodes will be applied and all conditions will be similar to those in the NMES group, except that the amplitude will be set to 0 mA so that no muscle stimulation occurs.
Group Type
SHAM_COMPARATOR
NMES no stimulation
Intervention Type
DEVICE
Placebo, electrode pad on, no stimulation
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
NMES new paradigm
stimulation frequency: 2 Hz; intensity: low amplitude; duration: 3 hours, 2 times per day for 8 weeks
Intervention Type
DEVICE
NMES conventional
stimulation frequency: 50 Hz; intensity: maximally tolerated; duration: 30 min per day for 8 weeks
Intervention Type
DEVICE
NMES no stimulation
Placebo, electrode pad on, no stimulation
Intervention Type
DEVICE
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* stable COPD patients who had been discharged from the medical unit, and had been admitted less than 2 times in the preceding year;
* patients drawn from either pulmonary rehabilitation program in Day Care Centre; or self help group; or home bound;
* COPD subjects with Forced Expiratory Volume at 1 sec (FEV1) to Forced Vital Capacity (FVC) ratio: ≤ 70%, oxygen uptake maximum (VO2 max) ≤ 8 MET and BMI ≤ 21kg/m2
* patients drawn from either pulmonary rehabilitation program in Day Care Centre; or self help group; or home bound;
* COPD subjects with Forced Expiratory Volume at 1 sec (FEV1) to Forced Vital Capacity (FVC) ratio: ≤ 70%, oxygen uptake maximum (VO2 max) ≤ 8 MET and BMI ≤ 21kg/m2
Exclusion Criteria
* subjects with known muscle wasting diseases such as motor neuron disease, cachexia, e.g. cancer cachexia;
* subjects with muscle dysfunction as a result of neurological conditions such as stroke, Parkinsonism
* subjects that can not comply with the study procedures (e.g. dementia)
* subjects with muscle dysfunction as a result of neurological conditions such as stroke, Parkinsonism
* subjects that can not comply with the study procedures (e.g. dementia)
Minimum Eligible Age
35 Years
Maximum Eligible Age
80 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
The Hong Kong Polytechnic University
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Simon S. Yeung
Associate Professor
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Simon S Yeung, PhD
Role: PRINCIPAL_INVESTIGATOR
The Hong Kong Polytechnic University
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University
Hung Hom, , Hong Kong
Site Status
RECRUITING
Countries
Review the countries where the study has at least one active or historical site.
Hong Kong
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
References
Explore related publications, articles, or registry entries linked to this study.
Paddon-Jones D, Sheffield-Moore M, Cree MG, Hewlings SJ, Aarsland A, Wolfe RR, Ferrando AA. Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress. J Clin Endocrinol Metab. 2006 Dec;91(12):4836-41. doi: 10.1210/jc.2006-0651. Epub 2006 Sep 19.
Reference Type
BACKGROUND
Greenhaff PL. The molecular physiology of human limb immobilization and rehabilitation. Exerc Sport Sci Rev. 2006 Oct;34(4):159-63. doi: 10.1249/01.jes.0000240017.99877.8a.
Reference Type
BACKGROUND
Fitts RH, Riley DR, Widrick JJ. Functional and structural adaptations of skeletal muscle to microgravity. J Exp Biol. 2001 Sep;204(Pt 18):3201-8. doi: 10.1242/jeb.204.18.3201.
Reference Type
BACKGROUND
Fitts RH, Riley DR, Widrick JJ. Physiology of a microgravity environment invited review: microgravity and skeletal muscle. J Appl Physiol (1985). 2000 Aug;89(2):823-39. doi: 10.1152/jappl.2000.89.2.823.
Reference Type
BACKGROUND
Adams GR, Caiozzo VJ, Baldwin KM. Skeletal muscle unweighting: spaceflight and ground-based models. J Appl Physiol (1985). 2003 Dec;95(6):2185-201. doi: 10.1152/japplphysiol.00346.2003.
Reference Type
BACKGROUND
Sheffler LR, Chae J. Neuromuscular electrical stimulation in neurorehabilitation. Muscle Nerve. 2007 May;35(5):562-90. doi: 10.1002/mus.20758.
Reference Type
BACKGROUND
Bax L, Staes F, Verhagen A. Does neuromuscular electrical stimulation strengthen the quadriceps femoris? A systematic review of randomised controlled trials. Sports Med. 2005;35(3):191-212. doi: 10.2165/00007256-200535030-00002.
Reference Type
BACKGROUND
Maddocks M, Gao W, Higginson IJ, Wilcock A. Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease. Cochrane Database Syst Rev. 2013 Jan 31;(1):CD009419. doi: 10.1002/14651858.CD009419.pub2.
Reference Type
BACKGROUND
Maffiuletti NA, Roig M, Karatzanos E, Nanas S. Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review. BMC Med. 2013 May 23;11:137. doi: 10.1186/1741-7015-11-137.
Reference Type
BACKGROUND
Petterson S, Snyder-Mackler L. The use of neuromuscular electrical stimulation to improve activation deficits in a patient with chronic quadriceps strength impairments following total knee arthroplasty. J Orthop Sports Phys Ther. 2006 Sep;36(9):678-85. doi: 10.2519/jospt.2006.2305.
Reference Type
BACKGROUND
Sillen MJ, Franssen FM, Gosker HR, Wouters EF, Spruit MA. Metabolic and structural changes in lower-limb skeletal muscle following neuromuscular electrical stimulation: a systematic review. PLoS One. 2013 Sep 3;8(9):e69391. doi: 10.1371/journal.pone.0069391. eCollection 2013.
Reference Type
BACKGROUND
Theriault R, Theriault G, Simoneau JA. Human skeletal muscle adaptation in response to chronic low-frequency electrical stimulation. J Appl Physiol (1985). 1994 Oct;77(4):1885-9. doi: 10.1152/jappl.1994.77.4.1885.
Reference Type
BACKGROUND
Napolis LM, Dal Corso S, Neder JA, Malaguti C, Gimenes AC, Nery LE. Neuromuscular electrical stimulation improves exercise tolerance in chronic obstructive pulmonary disease patients with better preserved fat-free mass. Clinics (Sao Paulo). 2011;66(3):401-6. doi: 10.1590/s1807-59322011000300006.
Reference Type
BACKGROUND
Banerjee P, Caulfield B, Crowe L, Clark AL. Prolonged electrical muscle stimulation exercise improves strength, peak VO2, and exercise capacity in patients with stable chronic heart failure. J Card Fail. 2009 May;15(4):319-26. doi: 10.1016/j.cardfail.2008.11.005. Epub 2009 Jan 29.
Reference Type
BACKGROUND
Banerjee P, Caulfield B, Crowe L, Clark A. Prolonged electrical muscle stimulation exercise improves strength and aerobic capacity in healthy sedentary adults. J Appl Physiol (1985). 2005 Dec;99(6):2307-11. doi: 10.1152/japplphysiol.00891.2004. Epub 2005 Aug 4.
Reference Type
BACKGROUND
Zhang BT, Yeung SS, Liu Y, Wang HH, Wan YM, Ling SK, Zhang HY, Li YH, Yeung EW. The effects of low frequency electrical stimulation on satellite cell activity in rat skeletal muscle during hindlimb suspension. BMC Cell Biol. 2010 Nov 18;11:87. doi: 10.1186/1471-2121-11-87.
Reference Type
RESULT
Guo BS, Cheung KK, Yeung SS, Zhang BT, Yeung EW. Electrical stimulation influences satellite cell proliferation and apoptosis in unloading-induced muscle atrophy in mice. PLoS One. 2012;7(1):e30348. doi: 10.1371/journal.pone.0030348. Epub 2012 Jan 12.
Reference Type
RESULT
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
HMRF12131991
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Mobilization With Neuromuscular Electrical Stimulation in Critical Care Patients
NCT02298114
UNKNOWN
NA
Neuromuscular Electroestimulation and Respiratory Muscle Training in Subacute Stroke
NCT02473432
COMPLETED
PHASE4
Electrical Stimulation in Patients With Prolonged Mechanical Ventilation
NCT02227810
COMPLETED
NA
Combined Neuromuscular Electrical Stimulation for Quadriceps and Triceps During Pulmonary Rehabilitation in COPD
NCT04684966
COMPLETED
NA
NMES Role to Prevent Respiratory Muscle Weakness in Critically Ill Patients and Its Association to Changes in Myokines.
NCT05536531
RECRUITING
NA
Inspiratory Muscle Training and Neuromuscular Electrical Stimulation in Chronic Obstructive Pulmonary Disease
NCT04387318
COMPLETED
NA
Effects of Neuromuscular Electrical Stimulation on Critically Ill Patients With Mechanical Ventilation
NCT05217511
UNKNOWN
NA
Sarcopenia and Intervention Physical Therapy
NCT07013604
NOT_YET_RECRUITING
NA
The Effect of Neuromuscular Electrical Stimulation
NCT00442728
COMPLETED
NA
Muscle Vibration as a Countermeasure Against Hypoactivity-induced
NCT07021079
RECRUITING
NA
Post-operative Electrical Muscle Stimulation to Stimulate Muscle Protein Synthesis in Humans
NCT05997095
ACTIVE_NOT_RECRUITING
NA
Neuromuscular Electrical Stimulation in Patients With Prolonged Mechanical Ventilation
NCT04076475
COMPLETED
NA
The Impact of Bed Rest, Aging and NMES on Skeletal Muscle
NCT05617222
UNKNOWN
NA
Neuromuscular Electrical Stimulation in Patients With Interstitial Lung Disease
NCT02497144
COMPLETED
NA
Muscle Strength Training in Lower Limb Amputee Patients
NCT07261852
NOT_YET_RECRUITING
NA
Treatment of Muscle Weakness in Critically Ill Patients
NCT02247895
TERMINATED
NA
Acute Effects After Stretching Respiratory Muscles on Ventilatory Pattern and Volume Distribution of Chest Wall
NCT02416349
COMPLETED
NA
A Method to Optimize Mecanical In-exsufflation in Neuromuscular Diseases
NCT02137304
COMPLETED
NA
Effect of Core Stabilization Exercises and Neuromuscular Electrical Stimulation in Patients With Idiopathic Pulmonary Fibrosis
NCT04197791
UNKNOWN
NA
Effect of Acu-Transcutaneous Electrical Nerve Stimulation (Acu-TENS) on Post-exercise Expiratory Flow Volume in Healthy Subjects
NCT00998179
COMPLETED
NA
Breath Stacking Technique Associated With Expiratory Muscle Training in Amyotrophic Lateral Sclerosis Patients
NCT04226144
TERMINATED
NA
High Protein, Core Muscle Rehab, Muscular Electrostimulation in Prolonged Mechanical Ventilation
NCT05932134
COMPLETED
NA
Inspiratory and Trunk Muscle Activity During IMT on Stable and Unstable Surfaces in Stroke Patients
NCT06877338
NOT_YET_RECRUITING
Resistance Exercise or Vibration With HMB for Sarcopenia
NCT04028206
UNKNOWN
NA
Transcutaneous Electrical Diaphragmatic Stimulation in Critically Ill Elderly Patients
NCT04565002
UNKNOWN
NA