The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training With Eccentric Loading

NCT ID: NCT06856629

Last Updated: 2025-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-01-31

Study Completion Date

2025-07-28

Brief Summary

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Decreasing workloads in strength training makes it more tolerable for a broad range of people. When designed as blood-flow restriction training, similar gains in strength and muscle mass are achieved compared to traditional training. Adding high training loads to blood-flow restriction training only in the eccentric phase (BFR-ECC) might achieve superior gains in muscle strength while still maximizing tolerability of the training stimuli.

This study aims to investigate the acute physiological and perceptual response of blood-flow restriction training with eccentric loading in comparison to traditional eccentric training. The study recruits healthy individuals ≥ 18 years.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

With random sequence allocation
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Eccentric blood-flow restriction trainig

Group Type EXPERIMENTAL

Eccentric blood-flow restriction training

Intervention Type OTHER

Eccentric blood-flow restriction training

Eccentric free-flow training

Group Type ACTIVE_COMPARATOR

Eccentric free-flow training

Intervention Type OTHER

Eccentric free-flow training

Interventions

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Eccentric blood-flow restriction training

Eccentric blood-flow restriction training

Intervention Type OTHER

Eccentric free-flow training

Eccentric free-flow training

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Clinically Healthy

Exclusion Criteria

* Physical or intellectual impairment precluding informed consent or protocol adherence
* Pain during exercise of any origin
* History of thromboembolic event in the lower extremity
* Known pregnancy (no testing is carried out)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Dario Kohlbrenner

OTHER

Sponsor Role lead

Responsible Party

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Dario Kohlbrenner

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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University of Zurich

Zurich, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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SNCTP000006261

Identifier Type: OTHER

Identifier Source: secondary_id

BASEC2024-02223

Identifier Type: -

Identifier Source: org_study_id

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