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Resistance Exercise Blood Flow Restriction

NCT ID: NCT06724458

Last Updated: 2024-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

29 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-28

Study Completion Date

2023-11-21

Brief Summary

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The number of repetitions able to be performed during resistance exercise is impacted by the load an individual is working against. Heavier loads lead to less repetitions being performed and lighter loads lead to more repetitions being performed. As the load gets progressively lighter, it is hypothesized that oxygen availability becomes an important factor for performance of maximum repetitions. Peripheral blood flow occlusion using exercise specific blood flow occlusion cuffs can allow for oxygen availability to be controlled by altering the amount of blood able to get to working muscles. To date, no study has examined the effect of varying exercise loads, from heavy to light, on maximum repetitions able to be performed with and without blood flow occlusion.

Detailed Description

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The study aims to assess the difference in maximum repetitions performed at varying percentages of participants maximum strength and the impact peripheral blood flow occlusion has on performance

The study will take three weeks to complete with a total of six visits. The entire time commitment will be seven hours. During week 1 participants will visit the lab twice to perform baseline assessments of strength, endurance, muscle size and will also receive a resting thighs muscle biopsy. During weeks 2 and 3 participants will visit the lab twice per week to complete three out of twelve randomized exercise interventions per visit. The interventions are maximum repetitions at 80/40/30/25/20/15% of knee-extension one-repetition maximum as well as 90/70/60/55/50/45% of barbell curl one-repetition maximum; all of the listed conditions will be tested in a free-flow and blood flow occluded state (i.e., 12 total exercise interventions for the knee extension and 12 total exercise interventions for the barbell curl).

Conditions

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Skeletal Muscle Endurance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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80% knee extension/80% barbell curl 1RM

The load will be set to 80% of 1RM for the knee extension and 80% 1RM for the barbell curl

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

40% knee extension/70% barbell curl 1RM

The load will be set to 40% of 1RM for the knee extension and 70% 1RM for the barbell curl

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

30% knee extension/60% barbell curl 1RM

The load will be set to 30% of 1RM for the knee extension and 60% 1RM for the barbell curl

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

25% knee extension/55% barbell curl 1RM

The load will be set to 25% of 1RM for the knee extension and 55% 1RM for the barbell curl

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

20% knee extension/50% barbell curl 1RM

The load will be set to 25% of 1RM for the knee extension and 50% 1RM for the barbell curl

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

15% knee extension/45% barbell curl 1RM

The load will be set to 15% of 1RM for the knee extension and 45% 1RM for the barbell curl

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

80% knee extension/80% barbell curl 1RM both with blood flow occlusion

The load will be set to 80% of 1RM for the knee extension and 80% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

40% knee extension/60% barbell curl 1RM both with blood flow occlusion

The load will be set to 40% of 1RM for the knee extension and 60% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

30% knee extension/60% barbell curl 1RM both with blood flow occlusion

The load will be set to 30% of 1RM for the knee extension and 60% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

25% knee extension/55% barbell curl 1RM both with blood flow occlusion

The load will be set to 25% of 1RM for the knee extension and 55% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

20% knee extension/50% barbell curl 1RM both with blood flow occlusion

The load will be set to 20% of 1RM for the knee extension and 50% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

15% knee extension/45% barbell curl 1RM both with blood flow occlusion

The load will be set to 15% of 1RM for the knee extension and 45% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

Interventions

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Resistance exercise

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Able to understand and communicate in English
2. 19-30 years of age
3. All "No" answers on the Canadian Society for Exercise Physiology Get Active questionnaire or doctors' approval to participate
4. Untrained participants: no structured resistance and/or endurance training over the past 12-months (i.e., \>2 hours per week of structured/periodized training)
5. Resistance trained participants: structured resistance training over the past 12-months (i.e., \>2 hours per week of structured/periodized resistance training)
6. Endurance trained participants: structured resistance training over the past 12-months (i.e., \>2 hours per week of structured/periodized endurance training)

Exclusion Criteria

1. BMI lower than 18 or greater than 30
2. Current use of cigarettes or other nicotine devices
3. Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
4. Any medical condition impacting the ability to participate in maximal exercise
5. Type one or type two diabetes
6. Diagnosis of cancer or undergoing cancer treatment in the past 12 months
7. Taking blood-thinning medication or the presence of a bleeding disorder
8. Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines)
9. Lowest calculated exercise testing load is less than the lightest weight able to be provided by the lab gymnasium equipment (i.e., 36 pounds for the knee extension, and/or 33 pounds for the barbell curl)
Minimum Eligible Age

19 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of British Columbia

OTHER

Sponsor Role lead

Responsible Party

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Cameron Mitchell

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Chan Gunn Pavilion

Vancouver, British Columbia, Canada

Site Status

Countries

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Canada

Other Identifiers

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BFRCL

Identifier Type: -

Identifier Source: org_study_id