Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men

NCT ID: NCT01905345

Last Updated: 2017-08-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-08-31

Study Completion Date

2017-08-31

Brief Summary

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Randomised training intervention.

Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell

Sarcopenia

Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible.

Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.

Detailed Description

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Conditions

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Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Endurance and Resistance Training

Endurance and resistance exercise

Group Type EXPERIMENTAL

Training

Intervention Type PROCEDURE

Resistance Training

resistance exercise (12wk)

Group Type EXPERIMENTAL

Training

Intervention Type PROCEDURE

Resistance and resistance Training

resistance exercise (24 wk)

Group Type EXPERIMENTAL

Training

Intervention Type PROCEDURE

Interventions

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Training

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* no fever at the beginning and during the study
* between 60 years and 75 years
* non smokers
* no known cardiovascular and orthopaedic problems
* no cardiac pacemaker
* fulfilling the health criteria

Exclusion Criteria

* fever or cold at the beginning or during the study
* non MRI compatible metal implants
* under 60 years or over 75 years
* smoker
* cardiovascular or orthopaedic problems
* cardiac pacemaker
* not fulfilling the health criteria
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hans H Jung, Prof MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Zurich, Division of Neurology

Locations

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University Hospital Zurich, Division of Neurology

Zurich, Canton of Zurich, Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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REGPOT

Identifier Type: -

Identifier Source: org_study_id

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