Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults
NCT ID: NCT01489930
Last Updated: 2011-12-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
67 participants
INTERVENTIONAL
2008-05-31
2011-02-28
Brief Summary
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Hypotheses.
1. to measure fractional synthesis rates of multiple muscle proteins and identify those that are enhanced by an endurance exercise program
2. to determine whether changes in protein synthesis in response to endurance exercise programs are dependent on age
3. to measure fractional muscle synthesis rates of multiple muscle proteins and to identify those that are enhanced by a resistance exercise program
4. to determine whether changes in protein synthesis in response to resistance exercise programs are dependent on age
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Endurance Exercise
Participants will perform 8-weeks of moderate intensity endurance (cycling) exercise
Endurance exercise
Participants will perform 8-weeks of endurance exercise training. Participants will train 5 days per week for 60 min at 65% of VO2 peak.
Resistance Exercise
Participants will perform 8-weeks of whole-body resistance exercise training.
Resistance exercise
Participants will perform 8-weeks of resistance exercise training. Participants will train 4 days per week for \~60 min. Two days will focus on lower body resistance training and two days will focus on upper body.
Control / Combined Training
Participants will perform 8-weeks of no exercise, followed by an additional 8-weeks of combined endurance plus resistance exercise training.
Control/Combined training
Participants will perform 8-weeks of no exercise (control), followed by 8-weeks of combined endurance and resistance training. Participants will endurance train 5 days per week for 30 min at 65% of VO2 peak and resistance train 4 days per week for 30 min.
Interventions
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Endurance exercise
Participants will perform 8-weeks of endurance exercise training. Participants will train 5 days per week for 60 min at 65% of VO2 peak.
Resistance exercise
Participants will perform 8-weeks of resistance exercise training. Participants will train 4 days per week for \~60 min. Two days will focus on lower body resistance training and two days will focus on upper body.
Control/Combined training
Participants will perform 8-weeks of no exercise (control), followed by 8-weeks of combined endurance and resistance training. Participants will endurance train 5 days per week for 30 min at 65% of VO2 peak and resistance train 4 days per week for 30 min.
Eligibility Criteria
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Inclusion Criteria
* 18 to 30 or \>65 years
* Males and Females
Exclusion Criteria
* Smoking
* Cardiometabolic Disease (diabetes, cardiovascular disease, thyroid disorders)
* Drugs known to impair metabolic function (beta blockers, steroids)
* Allergies to lidocaine
* Physical disability that precludes exercise
18 Years
ALL
Yes
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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K. Sreekumaran Nair
Professor of Medicine
Principal Investigators
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K. Sreekumaran Nair, MD, PD
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic
Rochester, Minnesota, United States
Countries
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References
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Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS. Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age. J Clin Endocrinol Metab. 2015 Apr;100(4):1654-63. doi: 10.1210/jc.2014-3081. Epub 2015 Jan 19.
Other Identifiers
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07-007689
Identifier Type: -
Identifier Source: org_study_id