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The Effect of Aging and Immobilisation on Muscle

NCT ID: NCT00559806

Last Updated: 2007-11-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2007-05-31

Brief Summary

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The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.

Detailed Description

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Conditions

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Healthy

Keywords

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immobilisation aging resistance training atrophy The effect of immobilisation in elderly compared to young individuals

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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1

9 healthy elderly males

Group Type EXPERIMENTAL

2 weeks of unilateral immobilisation and 4 weeks of resistance training

Intervention Type OTHER

2 weeks of whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control

2

11 healthy young males

Group Type EXPERIMENTAL

2 weeks of unilateral immobilisation and 4 weeks of resistance training

Intervention Type OTHER

2 weeks of unilateral whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control

Interventions

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2 weeks of unilateral immobilisation and 4 weeks of resistance training

2 weeks of whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control

Intervention Type OTHER

2 weeks of unilateral immobilisation and 4 weeks of resistance training

2 weeks of unilateral whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)

Exclusion Criteria

* Musculoskeletal disorder
* Diabetes
* Cardiovascular disease
* Neurological diseases; or
* Cognitive disorders
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Bispebjerg Hospital

OTHER

Sponsor Role lead

Principal Investigators

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Charlotte Suetta, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Institute of Sports Medicine Copenhagen, Bispebjerg Hospital

Locations

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Institute of Sports Medicine, Bispebjerg Hospital

Copenhagen, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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KF01-322606

Identifier Type: -

Identifier Source: org_study_id