Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study

NCT ID: NCT03404427

Last Updated: 2020-04-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 21 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-02-14
• Study Completion Date: 2020-03-04

Brief Summary

The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive.

During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force.

The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects.

Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control.

Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night.

Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.

Conditions

Sleep Deprivation; Healthy Volunteers; Skeletal Muscle

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

Normal sleep night

The first endurance test is the endurance motor control test after a normal sleep night.

Group Type: SHAM_COMPARATOR

Normal sleep night

Intervention Type: BEHAVIORAL

Usual hours of sleep

Sleepless night

The first endurance test is the endurance motor test after a sleepless night.

Group Type: EXPERIMENTAL

Sleepless night

Intervention Type: BEHAVIORAL

Total sleep deprivation the first night

Interventions

Normal sleep night

Usual hours of sleep

Intervention Type: BEHAVIORAL

Sleepless night

Total sleep deprivation the first night

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• adult male volunteers;
• 25 to 45 years old
• regularly sleeping more than 6 hours per night;
• no excessive consumers of coffee (<3 espressos / day);
• absence of muscular or neurological pathology ;
• with a BMI> 18 and <25 kg / m²;
• Horne and Ostberg score> 31 and <69 ;

Exclusion Criteria

• female sex
• history of neuromuscular disease ;
• implanted metallic or electronic equipment (vascular stent, ocular implant, pacemaker ...)
• history of epilepsy, or discomfort after sleep deprivation ;
• poor sleepers (PSQI> 5);
• exercising an activity in staggered hours;
• regularly performing more than 2 nights without sleep per month;
• taking drugs interfering with sleep (antidepressants, benzodiazepines ...);
• having crossed 4 time zones in the previous 4 weeks.
• current participation in another clinical research study;

• Minimum Eligible Age: 25 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Poitiers University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Xavier Drouot

Role: PRINCIPAL_INVESTIGATOR

Poitiers University Hospital

Locations

Centre Hospitalier de Poitiers

Poitiers, Vienne, France

Countries

France

References

Rault CCS, Heraud Q, Ansquer S, Ragot S, Kostencovska A, Thille AW, Stancu A, Saulnier PJ, Drouot X. Sleep Deprivation in Healthy Males Increases Muscle Afferents, Impairing Motor Preparation and Reducing Endurance. J Clin Neurophysiol. 2024 Nov 27;42(5):457-465. doi: 10.1097/WNP.0000000000001134.

Reference Type: DERIVED

PMID: 39593197 (View on PubMed)

Other Identifiers

HANDY-SLEEP

Identifier Type: -

Identifier Source: org_study_id