Autonomic Activity During Nap Under Hypoxia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-30

Study Completion Date

2020-12-30

Brief Summary

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Sleeping under hypoxic conditions can impair cognition and autonomic nervous activity. A short daytime nap can modify these changes. Here we propose a randomized, cross-over study to evaluate the heart rate variability during a 90 min nap in a normobaric hypoxic chamber. In addition, we will investigate sleep architecture, vigilance, attention and memory.

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Detailed Description

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Conditions

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Hypoxia Sleep Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Normoxia

20.9% oxygen

Group Type PLACEBO_COMPARATOR

Normoxia

Intervention Type OTHER

Nap in hypoxia chamber at 20.9% oxygen (36 m asl)

Hypoxia 1

15.0% oxygen

Group Type ACTIVE_COMPARATOR

Hypoxia 1

Intervention Type OTHER

Nap in hypoxia chamber at 15.0% oxygen (simulates 2660 m asl)

Hypoxia 2

12.8% oxygen

Group Type ACTIVE_COMPARATOR

Hypoxia 2

Intervention Type OTHER

Nap in hypoxia chamber at 12.8% oxygen (simulates 4000 m asl)

Interventions

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Normoxia

Nap in hypoxia chamber at 20.9% oxygen (36 m asl)

Intervention Type OTHER

Hypoxia 1

Nap in hypoxia chamber at 15.0% oxygen (simulates 2660 m asl)

Intervention Type OTHER

Hypoxia 2

Nap in hypoxia chamber at 12.8% oxygen (simulates 4000 m asl)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Men and women
* Age 25-45 years
* BMI 20 - 28 kg/m\^2

Exclusion Criteria

* Severe, manifest illnesses in need of treatment
* Postoperative phases
* Acute and chronic infections
* Sleep disorders such as sleep apnea, insomnia or somnolence
* Altitude exposure (\> 2500 m asl) within 6 months before enrollment
* Regular migraines
* Smoking
* Athletes
* Significant weight change within 1 month before enrollment
* Inability to understand significance and scope of the study
* Drug or alcohol abuse

Minimum Eligible Age

25 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes