Effects of Varying Duration of Naps on Cognitive Performance and Memory Encoding

NCT ID: NCT04984824

Last Updated: 2021-08-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-01

Study Completion Date

2021-06-15

Brief Summary

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To evaluate the nap duration that achieves maximal cognitive gain with practicality of implementation, the present work employs a within-subject design comparing nap durations of 10 minutes, 30 minutes, and 60 minutes with a no nap condition on benefits to alertness, vigilance, mood, speed of processing and memory over post-nap intervals of 5 minutes, 30 minutes, 60 minutes and 240 minutes. The effect of nap duration on memory encoding will also be examined.

Detailed Description

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Naps are a global phenomenon and a commonly adopted lifestyle countermeasure to reduce sleepiness and performance impairments. Experimental studies have also shown that naps can improve cognitive functioning and enhance memory and mood. However, the implementation of naps is highly varied amongst individuals, and it remains uncertain what duration of naps achieves the greatest cognitive benefit. Given the potential for naps to boost productivity in societies such as ours where insufficient nocturnal sleep is prevalent and where work hours are long, an investigation of the optimal nap duration is warranted.

Previous studies suggest that the benefits of brief naps (5-15 minutes) occur immediately after the nap and last a limited period (1-3 hours). Longer naps (\>30 minutes) are more likely to produce some temporary decrements due to sleep inertia but have the potential to improve cognitive performance for a more sustained period. These findings need to be strengthened through replication and extended to include memory measures that are evaluated over a longer post-nap testing period. To evaluate the nap duration that achieves maximal cognitive gain with practicality of implementation, the present work employs a within-subject design comparing nap durations of 10 minutes, 30 minutes, and 60 minutes with a no nap condition on benefits to alertness, vigilance, mood, speed of processing and memory over post-nap intervals of 5 minutes, 30 minutes, 60 minutes and 240 minutes. The effect of nap duration on memory encoding will also be examined.

The investigator's findings are expected to inform theoretical models of sleep and cognition and will aid in the design of practical lifestyle strategies to alleviate sleepiness and improve cognitive performance that may be adopted in an everyday context to boost societal well-being and productivity.

Conditions

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Sleep

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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No nap group

No nap opportunity will be given in this condition.

Group Type NO_INTERVENTION

No interventions assigned to this group

10 minute nap

Participants will be given a 10 minute nap.

Group Type EXPERIMENTAL

Nap duration

Intervention Type BEHAVIORAL

A cognitive battery which will be repeated at 1505, 1530, 1600 and 1900. Material for the picture encoding task will be learned at 1630 and will be tested at 2000.

30 minute nap

Participants will be given a 30 minute nap.

Group Type EXPERIMENTAL

Nap duration

Intervention Type BEHAVIORAL

A cognitive battery which will be repeated at 1505, 1530, 1600 and 1900. Material for the picture encoding task will be learned at 1630 and will be tested at 2000.

60 minute nap

Participants will be given a 60 minute nap.

Group Type EXPERIMENTAL

Nap duration

Intervention Type BEHAVIORAL

A cognitive battery which will be repeated at 1505, 1530, 1600 and 1900. Material for the picture encoding task will be learned at 1630 and will be tested at 2000.

Interventions

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Nap duration

A cognitive battery which will be repeated at 1505, 1530, 1600 and 1900. Material for the picture encoding task will be learned at 1630 and will be tested at 2000.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Participants aged from 21 - 35 years and who have an average sleep duration of 6-6.5 h are eligible for this study.

Exclusion Criteria

* Participants who have an average sleep duration of less than 6 h or more than 6.5 h, who report sleep apnea symptoms, who report drinking more than 5 cups of caffeinated drinks a day, who have a BMI greater or equal to 30, or report elevated depression or anxiety symptoms will be excluded.
Minimum Eligible Age

21 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Duke-NUS Graduate Medical School

OTHER

Sponsor Role lead

Responsible Party

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Michael WL Chee, MBBS

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michael Chee, MBBS

Role: PRINCIPAL_INVESTIGATOR

National University of Singapore

Locations

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Yong Loo Lin School of Medicine

Singapore, , Singapore

Site Status

Countries

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Singapore

References

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Leong RLF, Lau T, Dicom AR, Teo TB, Ong JL, Chee MWL. Influence of mid-afternoon nap duration and sleep parameters on memory encoding, mood, processing speed, and vigilance. Sleep. 2023 Apr 12;46(4):zsad025. doi: 10.1093/sleep/zsad025.

Reference Type DERIVED
PMID: 36775965 (View on PubMed)

Other Identifiers

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NapTitration

Identifier Type: -

Identifier Source: org_study_id

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