Neurobehavioral Effects of Partial Sleep Deprivation

NCT ID: NCT02128737

Last Updated: 2015-06-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 300 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-12-31
• Study Completion Date: 2015-04-30

Brief Summary

This project continues an innovative line of research on how to optimally use sleep as an intervention to promote cognitive recovery from, and resistance to, the neurobehavioral risks posed by chronic partial sleep deprivation. Chronic insufficient sleep is estimated to affect at least 20% of adults. It can result from medical conditions and sleep disorders, as well as work demands, and social or domestic responsibilities. It is associated with significant clinical morbidity, and directly causes errors and accidents that are due to its adverse neurobehavioral effects on alertness, mood, and cognitive functions. In seminal experiments conducted under this grant, we showed that the neurobehavioral effects of chronic sleep restriction accumulate to severe levels in a few days, without the full awareness of the affected individuals, and that recovery from chronic sleep restriction requires more sleep than previously assumed. We also discovered that recovery from chronic sleep was illusory, because it masked a heightened neurobehavioral vulnerability to even a single post-recovery night of sleep restriction. The implications of these findings are that apparent recovery from chronic sleep restriction masks a more severe cognitive response to subsequent sleep restriction suggesting that there are longer time constants in the brain for neurobehavioral recovery from chronic sleep restriction. In light of this finding, we now seek to determine whether additional nights of extended recovery sleep will reduce the heightened vulnerability induced by prior exposure to sleep restriction. A total of 87 healthy adults (ages 21-50) will be studied in the laboratory during a 17-night (N=63) and a 19-night (N=24) protocol evaluating cognitive, psychological and physiological responses to varying recovery days between two sleep-restriction periods. The results will establish the number of nights of recovery sleep needed to prevent accelerated deterioration during a subsequent period of sleep restriction. The findings will advance theoretical understanding of sleep homeostasis and its relationship to cognitive functions, as well as inform theories of sleep need, and have substantial implications for sleep biology, for the treatment of clinical disorders that regularly disrupt sleep, and for managing lifestyle factors that frequently restrict sleep.

Conditions

Control; 1 Night Recovery Sleep; 3 Nights Recovery Sleep; 5 Nights Recovery Sleep

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Control

10 hours time-in-bed all nights of study

Group Type: NO_INTERVENTION

No interventions assigned to this group

1 Recovery Night

2 baseline nights, five nights sleep restriction, 1 recovery night, five nights sleep restriction, 4 recovery nights

Group Type: EXPERIMENTAL

Sleep

Intervention Type: BEHAVIORAL

3 Recovery Nights

2 baseline nights, five nights sleep restriction, 3 recovery nights, five nights sleep restriction, 2 recovery nights

Group Type: EXPERIMENTAL

Sleep

Intervention Type: BEHAVIORAL

5 Recovery Nights

2 baseline nights, five nights sleep restriction, 5 recovery nights, five nights sleep restriction, 1 recovery nights

Group Type: EXPERIMENTAL

Sleep

Intervention Type: BEHAVIORAL

Interventions

Sleep

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

1. Age between 21 and 50 years (average age of our current protocols is 31 years)

2. Body mass index (BMI) within 20.5% of normal

3. Stable, normally-timed sleep-wake cycle as determined by interview, 2-week daily sleep log, and 2-week wrist actigraphic evidence, and defined by:

4. Habitual nocturnal sleep duration between 6.5h and 8.5h

5. Habitual morning awakening between 0600h and 0930h

Exclusion Criteria

1. No evidence of habitual napping

2. No shift work, transmeridian travel or irregular sleep/wake routine in the past 60 days

3. No sleep disorder, determined by history, actigraph, pulse oximetry and PSG

4. No history of mania or psychosis

5. No current depression as determined by the Beck Depression Inventory

6. No alcohol or drug abuse in the past year based upon history and urine toxicology screen

7. Not a current smoker

8. No acute, chronic, or debilitating medical conditions, major Axis I psychiatric illness, epilepsy, or thyroid disease, based on history, physical exam, blood and urine chemistries, and CBC

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institutes of Health (NIH)

NIH

Sponsor Role: collaborator

University of Pennsylvania

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

David F Dinges, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Pennsylvania

Locations

Unit for Experimental Psychiatry, Sleep and Chronobiology Laboratory

Philadelphia, Pennsylvania, United States

Countries

United States

References

Spaeth AM, Dinges DF, Goel N. Objective Measurements of Energy Balance Are Associated With Sleep Architecture in Healthy Adults. Sleep. 2017 Jan 1;40(1):zsw018. doi: 10.1093/sleep/zsw018.

Reference Type: DERIVED

PMID: 28364451 (View on PubMed)

Spaeth AM, Dinges DF, Goel N. Sex and race differences in caloric intake during sleep restriction in healthy adults. Am J Clin Nutr. 2014 Aug;100(2):559-66. doi: 10.3945/ajcn.114.086579. Epub 2014 Jun 25.

Reference Type: DERIVED

PMID: 24965304 (View on PubMed)

Other Identifiers

810896

Identifier Type: -

Identifier Source: org_study_id