A Change in Diet May Decrease the Negative Consequences of Chronic Sleep Deprivation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-09-30

Study Completion Date

2005-04-30

Brief Summary

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The purpose of this study is to determine whether or not a low calorie, low glycemic index diet with omega-3 fatty acid supplements can prevent some of the negative consequences of sleep deprivation.

Detailed Description

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This pilot study included 18 medical residents at two academic medical centers in New York City. All residents who participated in the study were assigned to work a night shift schedule for two weeks, and began the study on the morning prior to their first evening shift. The study subjects were randomly assigned to one of two groups:

* Intervention diet -- consisting of 40% carbohydrates, 30% protein, and 30% fat with 2.4g of long chain fatty acid supplements (n=9) Total calories for males was 1600/day, and 1200/day for females
* Control group -- ad lib diet.

Main outcome measures included:

* weight
* resting metabolic rate
* percent body fat
* lipid profile
* CRP
* fasting glucose and insulin levels
* urinary neurotransmitter levels
* salivary cortisol
* six cognitive tests of memory, attention, and executive function.

Subjects were tested on day 1, 7, and 14 of the study.

Conditions

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Sleep Deprivation

Keywords

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Diet Chronic sleep deprivation Weight Cognitive impairment Lipids Inflammation Resting metabolic rate Weight Gain Percent Body Fat Hyperlipidemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Interventions

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Controlled Dietary Intervention

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Medical resident in good standing at Cabrini Medical Center or Saint Vincent's Hospital, NY.
* Must be scheduled for two consecutive weeks of night shift work.

Exclusion Criteria

* Febrile illness
* Smoker
* Food allergies of any kind
* Taking any prescription medication
* History of diabetes or thyroid dysfunction
* Body mass index (BMI)\>30
* Pregnancy

Minimum Eligible Age

25 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Principal Investigators

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Valerie A Jones, MD

Role: PRINCIPAL_INVESTIGATOR

Saint Vincent's Hospital, Manhattan

Steven M Lascher, DVM

Role: STUDY_DIRECTOR

Saint Vincent's Hospital, Manhattan

Locations

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Saint Vincent's Hospital

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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IRB 77-04

Identifier Type: -

Identifier Source: org_study_id