Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
29 participants
INTERVENTIONAL
2016-03-01
2019-12-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Aging, Sleep, Cognitive Process
NCT00804804
Chronic Sleep Restriction
NCT01493661
Self-Management of Sleep Among Older Adults
NCT03837249
Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance
NCT00438438
Influence of Sleep Regularity on Circadian Rhythms, Learning, Performance, and Mood
NCT02839070
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Sleep deprivation young men
Young study participants will complete four nights in the sleep laboratory, whereas they will stay awake during one night. PET brain imaging will be conducted at the same circadian time on three consecutive afternoons (prior, during and after prolonged wakefulness). Additionally, validated tests of vigilance and cognitive performance will be administered and the brain waves will be recorded in wakefulness and sleep.
Prolonged wakefulness
40 hours of prolonged wakefulness
Sleep deprivation older men
Older study participants will complete four nights in the sleep laboratory, whereas they will stay awake during one night. PET brain imaging will be conducted at the same circadian time on three consecutive afternoons (prior, during and after prolonged wakefulness). Additionally, validated tests of vigilance and cognitive performance will be administered and the brain waves will be recorded in wakefulness and sleep.
Prolonged wakefulness
40 hours of prolonged wakefulness
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Prolonged wakefulness
40 hours of prolonged wakefulness
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* age: 20-35 or 60-70 years
* right-handed
* non-smokers
* moderate caffeine/alcohol consumption
* normal BMI
Exclusion Criteria
* former brain injuries with loss of consciousness and brain anomalies
* drug intake/consumption
* medication intake
* cardiac pacemaker
* neurological disorders
* prior participation (during past 2 years) in radiological or nuclear experiment
20 Years
70 Years
MALE
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University of Zurich
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Hanspeter Landolt, Prof
Role: PRINCIPAL_INVESTIGATOR
University of Zurich, Institute of Pharmacology and Toxicology
References
Explore related publications, articles, or registry entries linked to this study.
Weigend S, Holst SC, Treyer V, O'Gorman Tuura RL, Meier J, Ametamey SM, Buck A, Landolt HP. Dynamic changes in cerebral and peripheral markers of glutamatergic signaling across the human sleep-wake cycle. Sleep. 2019 Oct 21;42(11):zsz161. doi: 10.1093/sleep/zsz161.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
PSS-Sleep
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.