Study Results
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Basic Information
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COMPLETED
NA
28 participants
INTERVENTIONAL
2008-12-31
2011-02-28
Brief Summary
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Detailed Description
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Many studies have shown that extended wakefulness impairs nocturnal performances measured with a simple reaction time test (SRTT) and that this decrement is also age-related. In deed, young subjects (20-30 years) are more affected than old subjects (50-60 years) during an extended wakefulness period.
The results obtained in confinement constant conditions, associated to a high or low sleep pressure, show that this difference observed between young and old subjects should be essentially related to a reduced circadian regulation (ex : reduced melatonin secretion) with age rather than to a reduced sleep pressure (homeostatic regulation) as previously suggested. However, studies on confinement have shown that sleep pressure (identified during the sleep period with the EEG delta band) could be reduced with aging specifically on the anterior brain regions (frontal regions).
It is well-known that executive performances (related to frontal lobes functioning) are affected by extended wakefulness, but respective effects of age, circadian system and sleep pressure in this decrement remain unknown.
The aim of this study is to determine the evolution of the executive functions during a 40-hour extended wakefulness period ("high sleep pressure protocol") or during a multiple nap protocol ("low sleep pressure protocol") according to the subjects' age, in constant experimental conditions of confinement.
It's a repeated measurements study with protocol (sleep deprivation and multiple naps) and time of day as within factors and age group (young versus older subjects) as between factor
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Y1
young volunteers (20-30 years), morningness chronotype
Sleep deprivation and multiple rest
To determine the evolution of the executive functions during a 40-hour extended wakefulness period or during a 40-hour multiple nap protocol in constant experimental conditions of confinement
Y2
young volunteers (20-30 years), eveningness chronotype
Sleep deprivation and multiple rest
To determine the evolution of the executive functions during a 40-hour extended wakefulness period or during a 40-hour multiple nap protocol in constant experimental conditions of confinement
O1
Aged volunteers (65-75 years), morningness chronotype
Sleep deprivation and multiple rest
To determine the evolution of the executive functions during a 40-hour extended wakefulness period or during a 40-hour multiple nap protocol in constant experimental conditions of confinement
O 2
aged volunteers (65-75 years), eveningness chronotype
Sleep deprivation and multiple rest
To determine the evolution of the executive functions during a 40-hour extended wakefulness period or during a 40-hour multiple nap protocol in constant experimental conditions of confinement
Interventions
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Sleep deprivation and multiple rest
To determine the evolution of the executive functions during a 40-hour extended wakefulness period or during a 40-hour multiple nap protocol in constant experimental conditions of confinement
Sleep deprivation and multiple rest
To determine the evolution of the executive functions during a 40-hour extended wakefulness period or during a 40-hour multiple nap protocol in constant experimental conditions of confinement
Sleep deprivation and multiple rest
To determine the evolution of the executive functions during a 40-hour extended wakefulness period or during a 40-hour multiple nap protocol in constant experimental conditions of confinement
Sleep deprivation and multiple rest
To determine the evolution of the executive functions during a 40-hour extended wakefulness period or during a 40-hour multiple nap protocol in constant experimental conditions of confinement
Eligibility Criteria
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Inclusion Criteria
* sleep complaint such as sleep apnea or insomnia (Basic Nordic Sleep Questionnaire, items score \< 4 except questions 3, 4 and 15a for aged volunteers),
* not intermediate in terms of morningness and eveningness according to the Horne-Ostberg questionnaire for young volunteers
* absence of psychopathology evidenced during psychologist interview or on the Symptom Check List (SCL-90R score\>59)
* sleep efficiency evidenced by actimetry (\>85%) during 7 days
* absence of apnea/hypopnea syndrome (RDI\<15)
* absence of periodic movement disorder (MPS\<15)
* regular sleep schedule during 3 days before study participation
* affiliated to the french health care system
Exclusion Criteria
* poor sleep hygiene or abnormal usual sleep patterns,
* night workers or shift-workers,
* substance abusers (caffeine, drug, or alcohol).
20 Years
75 Years
MALE
Yes
Sponsors
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University Hospital, Bordeaux
OTHER
Responsible Party
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University Hospital, Bordeaux
Principal Investigators
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Pierre PHILIP, MD,PHD
Role: PRINCIPAL_INVESTIGATOR
University Hospital Bordeaux France
Locations
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Genpphass
Bordeaux, , France
Uh Purpan
Toulouse, , France
Medes-Imps
Toulouse, , France
Countries
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Other Identifiers
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CHUBX 2008/17
Identifier Type: -
Identifier Source: org_study_id
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