Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
NCT ID: NCT07085754
Last Updated: 2025-12-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2025-08-08
2026-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Sleep Deprivation
24 hours of sleep deprivation
Sleep Deprivation
Sleep deprivation for up to 24 hours with no naps or other sleep periods
Control
24 hours of a normal work-rest schedule
No interventions assigned to this group
Interventions
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Sleep Deprivation
Sleep deprivation for up to 24 hours with no naps or other sleep periods
Eligibility Criteria
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Inclusion Criteria
* Healthy (with no clinically significant abnormal findings in the physical examination report or self-reporting as healthy) and not on medications
* Cognitively normal (Mini-Mental State Examination (MMSE) score \> 28)
* Sleep duration of 7-9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) ≤ 5 points)
* Written informed consent, voluntarily participate in this study, and be able to cooperate with the physician to complete the clinical study
Exclusion Criteria
* Shift work within the past 6 months
* Travel across time zones or experience of jet lag within the past three weeks
* Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL \[or 8 g\] of pure alcohol)
* Consumption of strong tea, coffee, or caffeine-containing foods and beverages within one week before study participation
* Family history of early-onset dementia
* Self-Rating Depression Scale (SDS) score ≥ 53, Self-Rating Anxiety Scale (SAS) score ≥ 50
* Female participants who are currently pregnant or breastfeeding
* Individuals who need to drive or operate vehicles or machinery during the study period
18 Years
40 Years
ALL
Yes
Sponsors
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Yuhui Qiu
OTHER
Responsible Party
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Yuhui Qiu
Principal Investigator
Locations
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Guangdong Provincial Hospital of Chinese Medicine
Guangzhou, Guangdong, China
Countries
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Facility Contacts
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yuhui qiu
Role: primary
Other Identifiers
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ZF2025-206-01
Identifier Type: -
Identifier Source: org_study_id