Metabolic and Cognitive Parameters Following Partial Sleep Deprivation
NCT ID: NCT01823263
Last Updated: 2014-12-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2013-04-30
2015-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Partial sleep deprivation
Partial sleep deprivation: participants will have a 4-h sleep opportunity before a 'Blood Sample' will be taken, and the 'Memory tasks', 'Working memory function task' and 'Portion size task' will be performed. This will be followed by an 'Interference task', followed by repeated blood sampling and an 'Intake task'.
Portion Size Task
Participants are given a computer program that gives them the opportunity to choose the portions of a variety of food items that they would ideally like to consume
Blood sample
In the morning following partial sleep deprivation or normal sleep, a blood sample will be taken to assess the level of metabolism-linked and neurodegenerative-linked molecules, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as ghrelin
Interference task
30-minute interference task
Memory tasks
Participants will be allowed to learn a procedural memory task before going to bed. Participants will be retested in the morning to assess their change in performance. Other memory tests will also be given to assess the working memory performance in the morning following the intervention.
Intake task
After a normal night of sleep or partial sleep deprivation, participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window. Amount and selection will be recorded
Working memory function task
Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD)
Normal sleep
Normal sleep: participants will have an 8-h sleep opportunity before a 'Blood Sample' will be taken, and the 'Memory tasks', 'Working memory function task' and 'Portion size task' will be performed. This will be followed by an 'Interference task', followed with repeated blood sampling and an 'Intake task'.
Portion Size Task
Participants are given a computer program that gives them the opportunity to choose the portions of a variety of food items that they would ideally like to consume
Blood sample
In the morning following partial sleep deprivation or normal sleep, a blood sample will be taken to assess the level of metabolism-linked and neurodegenerative-linked molecules, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as ghrelin
Interference task
30-minute interference task
Memory tasks
Participants will be allowed to learn a procedural memory task before going to bed. Participants will be retested in the morning to assess their change in performance. Other memory tests will also be given to assess the working memory performance in the morning following the intervention.
Intake task
After a normal night of sleep or partial sleep deprivation, participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window. Amount and selection will be recorded
Working memory function task
Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD)
Interventions
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Portion Size Task
Participants are given a computer program that gives them the opportunity to choose the portions of a variety of food items that they would ideally like to consume
Blood sample
In the morning following partial sleep deprivation or normal sleep, a blood sample will be taken to assess the level of metabolism-linked and neurodegenerative-linked molecules, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as ghrelin
Interference task
30-minute interference task
Memory tasks
Participants will be allowed to learn a procedural memory task before going to bed. Participants will be retested in the morning to assess their change in performance. Other memory tests will also be given to assess the working memory performance in the morning following the intervention.
Intake task
After a normal night of sleep or partial sleep deprivation, participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window. Amount and selection will be recorded
Working memory function task
Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD)
Eligibility Criteria
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Inclusion Criteria
* Age 20-28y
* Healthy (self-reported) and not on medication
* Non-smoking
* Normal sleep-wake rhythm (i.e. 7-8 h per night, self-reported and verified by sleep diaries)
* Normal dietary habits (regular meal pattern with daily breakfast)
Exclusion Criteria
* Taking any serious medications
* Any sleep conditions (e.g. irregular bedtimes, sleep complaints)
* Any dietary issues with the food items provided
* A history of endocrine, neurological or psychiatric disorders
* Shift work in the previous 3 months
* Travel over several time zones within the previous two months
20 Years
28 Years
MALE
Yes
Sponsors
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Uppsala University
OTHER
Responsible Party
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Principal Investigators
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Christian Benedict, PhD
Role: PRINCIPAL_INVESTIGATOR
Department of Neuroscience, Uppsala University
Locations
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Department of Neuroscience, Uppsala University
Uppsala, Uppsala County, Sweden
Countries
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Central Contacts
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Facility Contacts
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Jonathan Cedernaes, M.D, PhD
Role: primary
Christian Benedict, PhD
Role: backup
Other Identifiers
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SleepPartialJCCB2013
Identifier Type: -
Identifier Source: org_study_id