Sleep and Memory in Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

71 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-02-29

Study Completion Date

2018-05-29

Brief Summary

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Sleep exerts a dual effect on learning: on the one hand, good sleep quality allows good daytime aptitudes leading to knowledge acquisition. On the other hand, sleep after learning is necessary for knowledge consolidation. A key role of sleep has clearly been demonstrated in memory consolidation in adults. Sleep leads to strengthen memory by promoting brain plasticity. Surprisingly, sleep influence on learning stabilization has scarcely been studied during childhood and in children affected by sleep disorders. Yet, sleep disorders concern almost 30% of children and are frequently related to a worsening in academic performances. Classical neuropsychological evaluations of these children, based on daytime learning, often fail to determine cognitive profiles explaining their academic difficulties. The investigators hypothesize that a lack of sleep-dependent consolidation could take an active part in these children's cognitive and academic difficulties. This proposal aims at characterizing interactions between sleep, learning and memory processes that have not been studied in children of elementary school age (6-12 years). The investigators will evaluate sleep-dependent memory consolidation processes in children with sleep disorders before and after treatment and healthy controls. Neuropsychological testing and academic performances will be also evaluated.. The comparison of performances obtained before and after medical treatment, will allow to understand whether normalisation of sleep quality permits the restoration of sleep-dependent memory consolidation.

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Detailed Description

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Conditions

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Sleep Apnea Temporo-central Epilepsy Narcolepsy High Intellectual Potential Healthy Subject

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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obstructive sleep apnoea

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from obstructive sleep apnoea syndrome.

Group Type EXPERIMENTAL

memory evaluation at V1 and V2 (with treatment)

Intervention Type OTHER

Overnight episodic and procedural memory consolidation performance will be assessed at V1 and V2. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance. The children receive drug treatment (BECTS and Narcolepsy) or surgical (OSA) as part of their routine care.

narcolepsy

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from narcolepsy.

Group Type EXPERIMENTAL

memory evaluation at V1 and V2 (with treatment)

Intervention Type OTHER

Overnight episodic and procedural memory consolidation performance will be assessed at V1 and V2. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance. The children receive drug treatment (BECTS and Narcolepsy) or surgical (OSA) as part of their routine care.

BECTS (Benign epilepsy with centro-temporal spikes)

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from BECTS.

Group Type EXPERIMENTAL

memory evaluation at V1 and V2 (with treatment)

Intervention Type OTHER

Overnight episodic and procedural memory consolidation performance will be assessed at V1 and V2. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance. The children receive drug treatment (BECTS and Narcolepsy) or surgical (OSA) as part of their routine care.

high intellectual potential

The objective of this task is to evaluate the sleep-dependent consolidation abilities in children with high intellectual potential.

Group Type EXPERIMENTAL

memory evaluation at V1 (without treatment)

Intervention Type OTHER

Overnight episodic and procedural memory consolidation performance will be assessed at V1. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance.

healthy children

The objective of this task is to evaluate the sleep-dependent consolidation abilities in healthy children.

Group Type EXPERIMENTAL

memory evaluation at V1 and V2 (without treatment)

Intervention Type OTHER

Overnight episodic and procedural memory consolidation performance will be assessed at V1 and V2. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance.

Interventions

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memory evaluation at V1 and V2 (with treatment)

Overnight episodic and procedural memory consolidation performance will be assessed at V1 and V2. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance. The children receive drug treatment (BECTS and Narcolepsy) or surgical (OSA) as part of their routine care.

Intervention Type OTHER

memory evaluation at V1 (without treatment)

Overnight episodic and procedural memory consolidation performance will be assessed at V1. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance.

Intervention Type OTHER

memory evaluation at V1 and V2 (without treatment)

Overnight episodic and procedural memory consolidation performance will be assessed at V1 and V2. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* aged between 6 and 12 y
* referred to the HFME for a suspicion of sleep apnea
* narcolepsy
* centro-temporal epilepsy
* high intellectual potential
* children without sleep disorders will be included in the healthy control group.

Minimum Eligible Age

6 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes