Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
NCT ID: NCT01840839
Last Updated: 2018-01-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
18 participants
INTERVENTIONAL
2013-10-31
2015-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
TRIPLE
Study Groups
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0,75 Hz stimulation
transcranial slow oscilliating stimulation (tSOS)during periods of SWS
brain stimulation
no stimulation
Sham stimulation during periods of SWS
Sham Stimulation
Interventions
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brain stimulation
Sham Stimulation
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* right handed
* inobtrusive neuropsychological examination
Exclusion Criteria
* epilepsy
* other severe neurological diseases eg., previous major stroke, brain tumour
* dementia
* contraindications to MRI
50 Years
90 Years
ALL
Yes
Sponsors
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Charite University, Berlin, Germany
OTHER
Responsible Party
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Agnes Flöel
Prof. Agnes Flöel, MD
Principal Investigators
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Agnes Flöel, Professor
Role: STUDY_CHAIR
Charite Universitätsmedizin Berlin - Neurologie
Agnes Flöel, Professor
Role: PRINCIPAL_INVESTIGATOR
Charite Universitätsmedizin Berlin - Neurologie
Locations
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Charite CCM Neurologie Berlin
Berlin, , Germany
Countries
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References
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Marshall L, Helgadottir H, Molle M, Born J. Boosting slow oscillations during sleep potentiates memory. Nature. 2006 Nov 30;444(7119):610-3. doi: 10.1038/nature05278. Epub 2006 Nov 5.
Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. 2010 Feb;11(2):114-26. doi: 10.1038/nrn2762. Epub 2010 Jan 4.
Ferrucci R, Mameli F, Guidi I, Mrakic-Sposta S, Vergari M, Marceglia S, Cogiamanian F, Barbieri S, Scarpini E, Priori A. Transcranial direct current stimulation improves recognition memory in Alzheimer disease. Neurology. 2008 Aug 12;71(7):493-8. doi: 10.1212/01.wnl.0000317060.43722.a3. Epub 2008 Jun 4.
Naismith SL, Lewis SJ, Rogers NL. Sleep-wake changes and cognition in neurodegenerative disease. Prog Brain Res. 2011;190:21-52. doi: 10.1016/B978-0-444-53817-8.00002-5.
Mednick SC, Cai DJ, Kanady J, Drummond SP. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res. 2008 Nov 3;193(1):79-86. doi: 10.1016/j.bbr.2008.04.028. Epub 2008 May 8.
Mander BA, Santhanam S, Saletin JM, Walker MP. Wake deterioration and sleep restoration of human learning. Curr Biol. 2011 Mar 8;21(5):R183-4. doi: 10.1016/j.cub.2011.01.019. No abstract available.
Mednick S, Nakayama K, Stickgold R. Sleep-dependent learning: a nap is as good as a night. Nat Neurosci. 2003 Jul;6(7):697-8. doi: 10.1038/nn1078.
Ladenbauer J, Kulzow N, Passmann S, Antonenko D, Grittner U, Tamm S, Floel A. Brain stimulation during an afternoon nap boosts slow oscillatory activity and memory consolidation in older adults. Neuroimage. 2016 Nov 15;142:311-323. doi: 10.1016/j.neuroimage.2016.06.057. Epub 2016 Jul 2.
Ladenbauer J, Ladenbauer J, Kulzow N, Floel A. Memory-relevant nap sleep physiology in healthy and pathological aging. Sleep. 2021 Jul 9;44(7):zsab002. doi: 10.1093/sleep/zsab002.
Other Identifiers
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Nap-tSOS-aged
Identifier Type: -
Identifier Source: org_study_id
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