The Evolution of Memories Across Wake and Sleep

NCT ID: NCT03227406

Last Updated: 2023-02-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 276 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-03-01
• Study Completion Date: 2023-01-31

Brief Summary

To further understanding of the relationship between sleep and memory the investigators will address and attempt to answer three questions, (1) how memories evolve across wake and sleep, (2) how different aspects of this memory evolution are reflected both behaviorally and in the EEG signal, and (3) what stages and features of sleep affect memory evolution. Together, these studies will provide a greater breadth and depth of knowledge concerning sleep's role in memory consolidation. Such knowledge would be of practical importance for educational practices, whether in schools, on the job, or in the military, and would also provide valuable information to the fields of sleep medicine and psychiatry, where interactions between sleep disorders and cognitive functioning are of great importance.

Detailed Description

Goal 1: How do memories evolve across wake and sleep? The investigators are interested in how specific memories are selected for change across periods of wake and sleep, and in characterizing the manner in which those memories change. There has been research into broad areas of memory, such as procedural and declarative memory, but other forms of memory, such as semantic memory, remain unexplored, as well as different subtypes of memory within these broad areas. Additionally, it is presently unknown how memories are selected for subsequent processing during sleep and wake. The investigators aim to characterize which memories change, how they are selected, and how they change differently over periods that include sleep versus periods during which participants remain awake.

Goal 2: How are these changes reflected behaviorally and in the EEG signal? The investigators will employ and develop specific behavioral and electrophysiological tasks and measures that allow one to probe the state of a particular type of memory and determine how it changes over periods of wake and sleep. EEG signals may be informative about the status of a memory during behavioral performance as well as during both waking and sleeping offline states.

Goal 3: What stages and features of sleep affect memory evolution? In the cases in which sleep in particular is found or suspected to influence memories in a unique way, the investigators will assess which stages and features of sleep are involved in that evolution. Generally, this will be accomplished by correlating measures such as time spent in a sleep stage, prominence of particular brain oscillations, or density of spindles with changes in behavior or in other EEG metrics

Conditions

Sleep Deprivation; Sleep

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Daytime Wake

Subjects are trained and retested during a single period of daytime wake

Group Type: NO_INTERVENTION

No interventions assigned to this group

Overnight sleep

Subjects are trained on one day and tested the next day, after a night of normal sleep

Group Type: NO_INTERVENTION

No interventions assigned to this group

Sleep deprivation

Subjects are trained on one day and tested the next day, after a night of sleep deprivation

Group Type: EXPERIMENTAL

Sleep deprivation

Intervention Type: BEHAVIORAL

Subjects are kept awake all night.

Daytime Nap

Subjects are trained and then retested after a daytime nap

Group Type: EXPERIMENTAL

Nap

Intervention Type: BEHAVIORAL

Participants are given a 90-minute nap opportunity in the early afternoon.

Interventions

Sleep deprivation

Subjects are kept awake all night.

Intervention Type: BEHAVIORAL

Nap

Participants are given a 90-minute nap opportunity in the early afternoon.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• willing and able to follow the protocol
• willing to refrain from alcohol and recreational drugs for the duration of the protocol
• in some cases, English as a first language, normal hearing, and/or normal or corrected to normal vision is required

Exclusion Criteria

• self-reported sleep disturbances
• a history of mental illness
• the use of any drugs that could affect either sleep or cognitive functioning (e.g., sleeping pills or antidepressants)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute of Mental Health (NIMH)

NIH

Sponsor Role: collaborator

Beth Israel Deaconess Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Robert Stickgold

Professor of Psychiatry

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Robert Stickgold, PhD

Role: PRINCIPAL_INVESTIGATOR

Beth Israel Deaconess Medical Center

Locations

Robert Stickgold

Boston, Massachusetts, United States

Countries

United States

Other Identifiers

R01MH048832

Identifier Type: NIH

Identifier Source: secondary_id

View Link

2016P000222

Identifier Type: -

Identifier Source: org_study_id