Sleep and Memory Consolidation in Adults With Attention Deficit Hyperactivity.

NCT ID: NCT05876286

Last Updated: 2023-09-21

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 36 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-10-15
• Study Completion Date: 2025-05-31

Brief Summary

Attention Deficit Disorder With Hyperactivity is associated with deficits in cognition and sleep. In healthy adults, memory consolidation processes are related to sleep spindle activity in the sleep electroencephalogram. This association is poorly characterized in adults with attention deficit hyperactivity. In this study, the purpose is to characterize sleep microarchitecture disorders through the analysis of different stage of sleep EEG activity during a polysomnographic examination in adult with mixed Attention Deficit Disorder With Hyperactivity presentation compared to healthy.

Conditions

Attention Deficit Disorder With Hyperactivity

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Attention Deficit Disorder With Hyperactivity

Patients with Attention Deficit Disorder With Hyperactivity. Same examinations than control group

Group Type: EXPERIMENTAL

Neurological examinations

Intervention Type: OTHER

Neurological, neuropsychological, polysomnography examinations and multiple sleep latency test. The protocol is divided into three visits.

Control

Healthy volunteers Same examinations than Attention Deficit Disorder With Hyperactivity group

Group Type: ACTIVE_COMPARATOR

Neurological examinations

Intervention Type: OTHER

Neurological, neuropsychological, polysomnography examinations and multiple sleep latency test. The protocol is divided into three visits.

Interventions

Neurological examinations

Neurological, neuropsychological, polysomnography examinations and multiple sleep latency test. The protocol is divided into three visits.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Age from 18 to 45 years old
• Affiliated to the French health care system

• meeting Diagnostic and Statistical Manual (DSM)-5 criteria for mixed attention deficit hyperactivity disorder presentation without drug treatment for attention deficit hyperactivity disorder.

Exclusion Criteria

• People not able to give consent, neurological disease (other than neurodevelopmental disorders; or any other serious disease (cancer, addiction, systemic disease)), untreated sleep apnea, major depression (Beck inventory > 15), untreated restless leg syndrome; pregnancy in progress or wish to become pregnant during the study or breastfeeding woman, drug treatment including benzodiazepine, neuroleptic or antidepressant before inclusion.

• Subjective cognitive and/or sleep complaint.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Toulouse

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Mélanie PLANTON, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Toulouse

Central Contacts

Mélanie PLANTON, PhD

Role: CONTACT

planton.m@chu-toulouse.fr

05 61 14 59 62 ext. 33

Other Identifiers

RC31/22/0488

Identifier Type: -

Identifier Source: org_study_id