Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
23 participants
INTERVENTIONAL
2021-07-11
2022-08-02
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Group A
Participants will have vascular function assessed following total sleep deprivation
Supervised Total Sleep Deprivation
Laboratory-monitored total sleep deprivation
Group B
Participants will have vascular function assessed following a full night of sleep
No interventions assigned to this group
Group C
Participants will have vascular function assessed following total sleep deprivation preceded by exercise
Exercise
60 minutes of moderate-intensity treadmill exercise (70% of maximal heart rate determined from the maximal graded exercise test)
Supervised Total Sleep Deprivation
Laboratory-monitored total sleep deprivation
Group D
Participants will have vascular function assessed following a full night of sleep
No interventions assigned to this group
Interventions
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Exercise
60 minutes of moderate-intensity treadmill exercise (70% of maximal heart rate determined from the maximal graded exercise test)
Supervised Total Sleep Deprivation
Laboratory-monitored total sleep deprivation
Eligibility Criteria
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Inclusion Criteria
* 20 to 30 and 50 to 60 years of age
* Females will be eumenorrheic at enrollment or postmenopausal for at least 1 year
* No major clinical disease (e.g., diabetes, cardiovascular, liver or chronic kidney disease) to minimize confounding of vascular measures
* Participants will be sedentary (≤3x per week of ≤30 minutes of aerobic exercise/session) or trained (≥5x per week of moderate/vigorous aerobic exercise training)
Exclusion Criteria
* Body mass index ≥30 kg/m\^2 because obesity may affect vascular function
* Use of medication that may affect vascular measures
* Hormone replacement therapy or hormonal contraceptives within past year
* Use of tobacco products (chewing tobacco, traditional or e-cigarettes) because they may influence vascular function
* Being perimenopausal, pregnant or lactating because may influence vascular function
* Being a shift worker because habitual sleep deprivation and altered circadian rhythm may influence vascular function.
* Not having an "intermediate" chronotype based on the Morningness-Eveningness Questionnaire (MEQ; score \<31 or \>69) because this would influence the effect of overnight sleep deprivation on vascular function.
* Sleep complaints based on the Pittsburgh Sleep Quality Index (PSQI; score \>5) because this would influence the effect of overnight sleep deprivation on vascular function.
20 Years
60 Years
ALL
Yes
Sponsors
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University of Florida
OTHER
Responsible Party
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Principal Investigators
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Demetra Christou, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Florida
Locations
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University of Florida
Gainesville, Florida, United States
Countries
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Other Identifiers
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IRB201901937
Identifier Type: -
Identifier Source: org_study_id
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