Effects of Partial Sleep Deprivation on Cardiac Output During Cycling

NCT ID: NCT06679543

Last Updated: 2025-03-25

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-01-02
• Study Completion Date: 2025-06-30

Brief Summary

The goal of this clinical trial is to determine if attenuations in cardiac output drive the blunted blood pressure response during cycling exercise following a night of partial sleep deprivation in young healthy adults (%50 females). The secondary outcome is to assess sex differences. The main questions it aims to answer are:

• Do reductions in plasma volume drive reductions in cardiac output and therefore blood pressure during exercise following a night of partial sleep deprivation?
• Do sex differences exist?

Participants will:

• Visit the lab after a night of normal sleep and a night of partial sleep deprivation.
• Keep a daily diary of their sleep and food/beverage intake.
• Perform maximal and submaximal exercise on a cycle ergometer.

Detailed Description

The investigators recently published data showing systolic blood pressure is attenuated during cycling exercise in males but not females following acute partial sleep deprivation, compared to a night of normal sleep, despite no differences in power output. The mechanisms responsible for this sex difference remain unknown. The investigators have pilot data that suggests males have a reduction in cardiac output following acute partial sleep deprivation, but females do not. Therefore, the primary purpose of this study is to assess hemodynamics (blood pressure, stroke volume, and cardiac output) and plasma volume during cycling exercise following a night of normal sleep and partial sleep deprivation in otherwise healthy males and females.

Thirty young healthy adults (50% female) will be recruited to undergo three visits. The first visit will assess maximal oxygen uptake to determine aerobic fitness and metabolic exercise intensity zones. The following two testing visits will be randomized and will be completed after a night of normal sleep or acute partial sleep deprivation (early awakening, 40% normal sleep duration). Sleep will be measured 1-week before each visit subjectively (questionnaire) to determine habitual sleep timing and duration and objectively (wrist actigraphy) the night before each testing visit. Each testing visit will require participants to complete a constant load 60-minute bout of cycling. Before, during, and after the exercise protocol, the investigators will measure hemodynamics and plasma volume. Venous blood samples will be collected via intravenous lines.

Conditions

Sleep Deprivation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Normal sleep

During this arm, participants will be asked to come to the lab for testing after a night of normal sleep. Normal sleep will be defined as participants habitual sleep-wake timing.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Partial sleep deprivation

During this arm, participants will be asked to come to the lab for testing after a night of partial sleep deprivation. Participants will be asked to fall asleep at their habitual bedtime but wake up early (\~40% of normal sleep duration).

Group Type: EXPERIMENTAL

Partial sleep deprivation

Intervention Type: OTHER

Participants will be asked to come to the lab for testing after a night of partial sleep deprivation. Participants will be asked to fall asleep at their habitual bedtime but wake up early (\~40% of normal sleep duration).

Interventions

Partial sleep deprivation

Participants will be asked to come to the lab for testing after a night of partial sleep deprivation. Participants will be asked to fall asleep at their habitual bedtime but wake up early (\~40% of normal sleep duration).

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Free of known cardiovascular or metabolic diseases or sleep disorders
• No history of smoking (within the past 3 months)
• Able to engage in physical activity assessed through the physical activity readiness questionnaire (PAR-Q+)
• No prescription of chronic medications other than oral contraceptives
• Able to abide by sleep protocols for all visits
• Individuals who are not allergic to ultrasound gel
• Individuals who are not pregnant

Exclusion Criteria

• Individuals diagnosed with cardiovascular or metabolic disease or sleep disorders
• Has a history of smoking (within the past 3 months)
• Not ready to engage in physical activity as assessed by the PAR-Q+
• Individuals prescribed chronic medications other than oral contraceptives
• Unable to abide by sleep protocols for any testing visit
• Allergic to ultrasound gel
• Pregnancy

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Guelph

OTHER

Sponsor Role: lead

Responsible Party

Philip Millar

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Julian Bommarito, MSc

Role: STUDY_DIRECTOR

University of Guelph

Philip Millar, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Guelph

Locations

University of Guelph

Guelph, Ontario, Canada

Site Status: RECRUITING

Countries

Canada

Central Contacts

Julian Bommarito, MSc

Role: CONTACT

jbomma01@uoguelph.ca

9052209829

Facility Contacts

Julian Bommarito, MSc

Role: primary

jbomma01@uoguelph.ca

9052209829

Other Identifiers

24-03-017

Identifier Type: -

Identifier Source: org_study_id