The Effects of Night Shift Work on Health Across the Menstrual Cycle

NCT ID: NCT06683248

Last Updated: 2024-11-14

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-04-25
• Study Completion Date: 2025-12-31

Brief Summary

The study aims to investigate the effects of sleep deprivation on women's health across different phases of the menstrual cycle.

Detailed Description

Modern society demands around-the-clock services, with an estimated 20% of workers involved in night shifts. Shift work disrupts the circadian rhythm and has been linked to increased risks of obesity, metabolic syndrome, glucose dysregulation, and immune system issues. Sleep deprivation, especially during wakeful nights, is associated with elevated levels of central nervous system biomarkers like Tau and Amyloid-β proteins, which are implicated in brain disorders such as Alzheimer's disease.

However, the effects of sleep deprivation on women, particularly in relation to hormonal fluctuations during the menstrual cycle, remain largely unexplored. The menstrual cycle, which occurs in cis-women of childbearing age, involves significant fluctuations in estrogen, a hormone known for its neuroprotective properties. Estrogen impacts memory, executive function, and may play a role in protecting against neurodegenerative conditions like Alzheimer's disease. Previous studies have largely focused on men or women using hormonal contraceptives, leaving a gap in understanding how natural hormonal cycles impact the response to sleep deprivation.

This study addresses this gap by focusing on healthy young women with regular menstrual cycles who do not use hormonal contraceptives. Participants will undergo an adaptation night followed by a sleep condition and a wake condition experiment. The goal is to better understand how hormonal changes throughout the menstrual cycle influence the body's response to sleep deprivation and stress, particularly in areas such as metabolism, brain function, and immune, system, and microbiota.

Conditions

Sleep Deprivation; Menstrual Cycle; Brain Health; Metabolism; Microbiota; Immune System

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: NONE

Study Groups

Sleep deprivation

All participants will undergo an 8-hour sleep opportunity, immediately followed by a night of total sleep deprivation.

Group Type: EXPERIMENTAL

Investigate sleep deprivation

Intervention Type: OTHER

Sleep deprivation

Devices used:

Dreem band for EEG Actiheart Tobii Eye tracker Blood glucose monitor Blood pressure cuff Mira fertility tracker Galvanic skin response K5: wearable metabolic system Fitbit: wearable technology Withings sleep analyzer Body composition monitor

Interventions

Investigate sleep deprivation

Sleep deprivation

Devices used:

Dreem band for EEG Actiheart Tobii Eye tracker Blood glucose monitor Blood pressure cuff Mira fertility tracker Galvanic skin response K5: wearable metabolic system Fitbit: wearable technology Withings sleep analyzer Body composition monitor

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy

Exclusion Criteria

• Use of hormonal contraceptives
• Chronic disease
• Regular use of nicotine
• Use of medication
• Consumes excessive amounts of alcohol or coffee

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Uppsala University

OTHER

Sponsor Role: lead

Responsible Party

Christian Benedict

Senior lecturer

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Uppsala University

Uppsala, Uppsala County, Sweden

Site Status: RECRUITING

Countries

Sweden

Central Contacts

Christian Benedict, PhD

Role: CONTACT

christian.benedict@farmbio.uu.se

+4618-471 4148

Meth

Role: CONTACT

Facility Contacts

Christian Benedict, PhD

Role: primary

christian.benedict@farmbio.uu.se

Other Identifiers

2021-04191

Identifier Type: -

Identifier Source: org_study_id