Metabolic Implications of Day and Night-shift Working on NHS Healthcare Staff

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-01

Study Completion Date

2024-04-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The investigators will conduct an open label, experimental medicine study exploring the acute metabolic impact of night-shift compared to day-shift work in NHS healthcare workers. Employees who are scheduled to work both day and night shifts will be recruited and identical metabolic investigations will be performed in the same participant following at least 3 consecutive day and night-shifts respectively. These investigations will take place at the Clinical Research Unit (CRU) in Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) at Churchill Hospital. The order of post-day and post-night shift investigations will be randomly determined and there will be a 2-week minimum interval between both sets of investigations. Participants will complete a self-reported food diary before and during each set of shifts (both day and night) and will have wrist-watch actigraphy performed throughout the entire study period in order to measure sleep and activity parameters. All study visits and investigations will commence at the CRU at 8am and will include a 2-step hyperinsulinaemic euglycaemic clamp with stable isotope infusions.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Development of Countermeasures Against Adverse Metabolic Effects of Shift Work

NCT02291952

Circadian Dysregulation

COMPLETED NA

Biological Rhythms Impact of 12 Hours Shift Work

NCT03153917

Shift-Work Sleep Disorder

COMPLETED NA

The Metabolic and Circadian Effects of Shift Work

NCT05177965

Shift Work Schedule

COMPLETED

Cardiometabolic Risk of Shiftwork

NCT01264913

Sleep Deprivation Circadian Dysregulation Shift-Work Sleep Disorder

TERMINATED

Night Shift Work and Biomarkers of Obesity Risk in Hospital and Industry Workers

NCT06288568

Obesity Shift-work Disorder Circadian Rhythm Disorders

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Shift-work Disorder

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Metabolic investigations after night-shifts

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Male or female
* National Health Service (NHS) worker with rotating night and day shift working patterns
* Age 18-75 years

Exclusion Criteria

* A diagnosis of type 1 or type 2 diabetes
* Pregnancy
* A blood haemoglobin \<120mg/dL
* History of alcohol use disorder or a greater than recommended alcohol intake (Recommendations \> 21 units on average per week for men and \> 14 units on average per week for women)
* Other conditions or co-morbidities that in the eyes of the investigators may affect data collection
* Any condition in the opinion of the investigator that might impact upon safety or validity of the results
* Primary sleep disorder
* Current glucocorticoid use
* Current melatonin use
* Patients with known non-alcoholic steatohepatitis or advanced hepatic fibrosis/cirrhosis

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No