The Metabolic and Circadian Effects of Shift Work

NCT ID: NCT05177965

Last Updated: 2025-11-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 72 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-02-01
• Study Completion Date: 2024-08-30

Brief Summary

In an exploratory observational pilot study, the investigators will focus on the effects of short-term circadian misalignment induced by shift work on multidimensional measurements including glucose excursion, metabolic health, circadian rhythms (measured in vitro and in vivo), sleep/wake cycles and ambient light, eating and activity patterns, well-being and attention.

Conditions

Shift Work Schedule

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Shift workers

Measurements repeated during a series of day shifts and during a series of night shifts

Exposure to shift work

Intervention Type: OTHER

Detailed questionnaire adapted from the Standard Shiftwork Index, measured at inclusion

Interventions

Exposure to shift work

Detailed questionnaire adapted from the Standard Shiftwork Index, measured at inclusion

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Men and women
• Age 20-50 years
• Working ≥ 80% full-time equivalent over the previous month and during the study
• Working night shifts (i.e. shifts that comprise working hours between 23h and 06h) in rotation with day shifts (i.e. shifts that comprise working hours between 06h and 20h)
• Planned to work at least 3 consecutive night shifts during the study preceded by at least a day off or day shift
• Planned to work at least 3 consecutive day shifts during the study
• Confident use of a smartphone compatible with the study application (iOS, Android) and able to regularly take pictures of consumed food/drinks
• Able to give a fully informed consent and follow the study procedures

Exclusion Criteria

• Planned or current pregnancy during the study
• Menopausal women
• Major illness or hospitalization over the previous month
• Carries a pacemaker, pump or other medical device that can be disabled by a magnet
• Major mental illness
• Trip to a different time zone (≥ 2-hour time difference) over the previous month or planned during the study
• Enrolled in an interventional clinical trial (potentially interfering with the main outcomes) over the previous month or planned during the study

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Tinh-Hai Collet, MD

OTHER

Sponsor Role: lead

Responsible Party

Tinh-Hai Collet, MD

Principal Investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Tinh-Hai Collet, MD

Role: PRINCIPAL_INVESTIGATOR

Geneva University Hospitals, Geneva

Locations

Geneva University Hospitals

Geneva, , Switzerland

Countries

Switzerland

References

Hartmeyer SL, Phillips NE, Jassil FC, Joris C, Dibner C, Collet TH, Andersen M. Multi-Wearable Approach for Monitoring Diurnal Light Exposure and Body Rhythms in Nightshift Workers. Acta Physiol (Oxf). 2025 Jul;241(7):e70069. doi: 10.1111/apha.70069.

Reference Type: RESULT

PMID: 40485643 (View on PubMed)

Other Identifiers

2021-01088

Identifier Type: -

Identifier Source: org_study_id