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Effect of Partial Sleep Deprivation on Immunological System in Peripheral Blood

NCT ID: NCT01930279

Last Updated: 2013-08-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-09-30

Study Completion Date

2014-09-30

Brief Summary

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Sleep deprivation was found to affect many organs including the immune system and predisposing for various health consequences including diabetes hypertension infections and increase in neoplastic diseases.

Subjects will be evaluated for immune parameters in peripheral blood test following a regular nigh sleep and compared with a test performed following a night shift in which they slept less than 3 hours.

Each participant will serve as its own control.

Detailed Description

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Overall Study Design and Plan

1. Subjects will be bled on the day of the experiment between 8and 9 AM.
2. Blood tubes will be tested for T cell markers, serum cytokines levels, and other immune parameters by western blots.
3. The first tube will be tested on the day of experiment.
4. The second tube will kept in the lab and will be tested 24 hours later.
5. The third tube will be kept in the pocket of the subject and be tested 24 hours later.
6. The fourth tube will be kept in the pocket of another subject and will be tested 24 hours later.
7. The subject will be tested again following 24 hours.
8. Each subject will be tested twice following a regular 6-8 hours of sleep, and following an on call duty in which he slept less than 3 hours.

Conditions

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Sleep Deprivation

Keywords

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T cell markers

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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surface markers on T cells as assessed by FACS

Blood withdrawal

Intervention Type OTHER

Blood withdrawal

Interventions

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Blood withdrawal

Blood withdrawal

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Male and female ages 18-40 signed confirmed consent no evidence of chronic disease or chronic medications

Exclusion Criteria

Any type of acute infection or other acute illness
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hadassah Medical Organization

OTHER

Sponsor Role lead

Responsible Party

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ayman abu rmaileh

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Hadassah Medical Organization

Jerusalem, Jerusalem, Israel

Site Status

Countries

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Israel

Central Contacts

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Ayman Abu rmeileh, MD

Role: CONTACT

Phone: 0584400010

Email: [email protected]

Tawfik Khoury, MD

Role: CONTACT

Phone: 0509870611

Email: [email protected]

Facility Contacts

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Ayman Abu Rmeileh, MD

Role: primary

Tawfik Khoury, MD

Role: backup

Other Identifiers

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LDB001

Identifier Type: -

Identifier Source: org_study_id