Sleep and Vascular Health Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-01

Study Completion Date

2025-05-05

Brief Summary

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Habitual short sleep duration (\< 7 hours/night) increases the risk of cardiovascular disease (CVD) and all-cause mortality. Yet most adults, especially emerging adults (i.e., 18-25 years) do not achieve the National Sleep Foundation recommendation of 7-9 hours of sleep each night. Additionally, the American Heart Association recently included sleep duration in the "Life's Essential 8". This recent development emphasizes the importance of sleep and the need to advance our understanding of how sleep impacts cardiometabolic health (CMH), particularly in emerging adults, a population whose CVD risk trajectory is malleable. Specifically, emerging adulthood is a critical age window when age-related loss of CMH accelerates. Based on my previous work and others, both self-reported and objective measures of poor sleep (e.g., duration, variability) are linked to early signs of elevated CVD risk in emerging adults, such as microvascular dysfunction and elevated central blood pressure (BP), which precede the development of hypertension.

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Detailed Description

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The investigators aim to address the knowledge gap on whether sleep extension is a viable strategy to improve CMH in emerging adults with habitual short sleep duration. A prior study demonstrated the feasibility of sleep extension to improve BP and perceived sleepiness in predominantly normotensive emerging adults (18-23 years). Even without hypertension, reductions in BP are generally beneficial for CMH. The research hypothesis is that sleep extension (one extra hour in bed per night) will improve CMH and health behaviors in emerging adults who self-report \< 7 hours of sleep per night. The primary aim is to determine if sleep extension is effective in improving BP. Investigators will assess CMH after habitual sleep (2 weeks) followed by a 2-week sleep extension intervention in 60 emerging adults (\~30 female).

Conditions

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Sleep Vascular Diseases Metabolic Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Participants will serve as their own controls. Due to the nature of the intervention (extending time in bed by 1 hour) all participants will be measured in their habitual sleep state followed by their extended sleep state.

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Habitual Sleep

Participants will follow their normal sleep schedule for 2 weeks.

Group Type NO_INTERVENTION

No interventions assigned to this group

Sleep extension

Participants will extend their time in bed by one hour for 2 weeks while being monitored.

Group Type EXPERIMENTAL

Sleep Extension

Intervention Type BEHAVIORAL

Participants will extend their time in bed by one hour for 2 weeks while being monitored.

Interventions

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Sleep Extension

Participants will extend their time in bed by one hour for 2 weeks while being monitored.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 18 - 25 years old
* self-report sleeping less than 7 hours a night on average
* free from metabolic disease
* free from liver disease
* free from pulmonary disease
* free from cardiovascular disease

Exclusion Criteria

* blood pressure higher than 140/80 mmHg
* BMI greater than 35 kg/m2
* use of blood thinners
* history of sleeping disorders
* no severe food allergies or eating disorders

Minimum Eligible Age

18 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes