Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
32 participants
INTERVENTIONAL
2016-12-01
2017-05-26
Brief Summary
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The investigators here examine in healthy participants, whether there are shared brain mechanisms underlying galvanic vestibular stimulation, illusory self-motion and egocentric transformation, as well as their interaction.
It is hypothesized that the GVS induced illusory self-motion dampens the ability to perform egocentric mental transformation.
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Detailed Description
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The primary objective is to reveal which brain area(s) are involved in the interaction of illusory self-motion (as induced by galvanic vestibular stimulation (GVS)) and egocentric mental transformation, as compared to no illusory self-motion or object-based mental transformation. It is hypothesized that the GVS induced illusory self-motion dampens the ability to perform egocentric mental transformation more than object-based mental transformation.
As previous behavioral studies on such an interaction were always done in a sitting position, a secondary objective is to first replicate previous behavioral mental rotation studies that used GVS, in the Magnetic Resonance (MR) -scanner comparable setting. Moreover, as no brain imaging study so far has investigated subjective illusory motion experience induced by GVS, illusory self-motion will be measured and included in the statistical model to find specific brain regions modulating the illusory self-motion perception.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Galvanic Vestibular Stimulation
A standard placement of the electrodes will be used for GVS and sham, placed on the mastoids. Weak currents up to maximally 3 mA will be used (tested before in each participant individually, and expected mean current will be around 1.5 mA). Previous studies have used Magnetic Resonance (MR) compatible GVS without reporting any discomfort for the participants, however weak sensations of nausea could be possible and in case that they are disturbing for the participants the experiment will be aborted. Continuous stimulation for up to 30min with intensities of 1-1.5 mA is generally considered as safe and free of any considerable side effects.
Galvanic Vestibular Stimulation
The investigators aim to study the influence of Galvanic Vestibular Stimulation on the brain mechanisms underlying illusory self-motion and its influence on egocentric mental transformation. As a control condition sham stimulation will be applied by the same device within the same participants in different trials. Participants should not note the difference.
Interventions
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Galvanic Vestibular Stimulation
The investigators aim to study the influence of Galvanic Vestibular Stimulation on the brain mechanisms underlying illusory self-motion and its influence on egocentric mental transformation. As a control condition sham stimulation will be applied by the same device within the same participants in different trials. Participants should not note the difference.
Eligibility Criteria
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Inclusion Criteria
* Written informed consent by the participant
* Right handed
Exclusion Criteria
* claustrophobia
* no ability to lie still in the scanner, e.g. a cold leading to frequent sneezing and subsequent head movements
* history of neurological or psychiatric disorder
* hearing problems
* concomitant medication
* strong motion sensitivity
* vestibular deficits
18 Years
55 Years
MALE
Yes
Sponsors
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University of Zurich
OTHER
Responsible Party
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Principal Investigators
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Lars Michels, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital Zurich, Div. of Neuroradiology
Other Identifiers
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2016-00464
Identifier Type: -
Identifier Source: org_study_id
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