tDCS Effects on GABA Concentration and Brain Functional Connectivity in Older Adults Of Working Age
NCT ID: NCT02794272
Last Updated: 2017-01-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
24 participants
INTERVENTIONAL
2016-04-30
2016-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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Anodal tDCS
Anodal stimulation during resting state fMRI
tDCS
Cathodal tDCS
Cathodal stimulation during resting state fMRI
tDCS
sham tDCS
Sham stimulation during resting state fMRI
sham-tDCS
Interventions
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tDCS
sham-tDCS
Eligibility Criteria
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Inclusion Criteria
* age: older adults of working age: 50-65 years
Exclusion Criteria
* History of severe alcoholism or use of drugs.
* Severe psychiatric disorders such as depression, psychosis (if not in remission) and severe untreated medical problems.
* Contraindication for MRI (claustrophobia, metallic implants, ferromagnetic metals in the body, disorders of thermoregulation, pregnant women).
50 Years
65 Years
ALL
Yes
Sponsors
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Physikalisch-Technische Bundesanstalt Institut Berlin (PTB)
OTHER
Charite University, Berlin, Germany
OTHER
Responsible Party
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Agnes Flöel
Prof. Dr.
Principal Investigators
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Agnes Flöel, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
Charite University, Berlin, Germany
Locations
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Charité Universitätsmedizin Berlin
Berlin, State of Berlin, Germany
Countries
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References
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Bachtiar V, Near J, Johansen-Berg H, Stagg CJ. Modulation of GABA and resting state functional connectivity by transcranial direct current stimulation. Elife. 2015 Sep 18;4:e08789. doi: 10.7554/eLife.08789.
Amadi U, Allman C, Johansen-Berg H, Stagg CJ. The Homeostatic Interaction Between Anodal Transcranial Direct Current Stimulation and Motor Learning in Humans is Related to GABAA Activity. Brain Stimul. 2015 Sep-Oct;8(5):898-905. doi: 10.1016/j.brs.2015.04.010. Epub 2015 May 1.
Stagg CJ, Bachtiar V, Amadi U, Gudberg CA, Ilie AS, Sampaio-Baptista C, O'Shea J, Woolrich M, Smith SM, Filippini N, Near J, Johansen-Berg H. Local GABA concentration is related to network-level resting functional connectivity. Elife. 2014 Mar 25;3:e01465. doi: 10.7554/eLife.01465.
Other Identifiers
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TRAINSTIM1.B
Identifier Type: -
Identifier Source: org_study_id
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