Transcranial Direct Current Stimulation (tDCS) in Chronic Neuropathy
NCT ID: NCT02747758
Last Updated: 2023-03-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
17 participants
INTERVENTIONAL
2016-09-19
2021-01-31
Brief Summary
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Detailed Description
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One innovative therapeutic option for pain patients is transcranial direct current stimulation (tDCS): In recent clinical trials, patients reported on reduced overall pain intensity following tDCS stimulation series shown e.g. from Bolognini et al., Antal et al. and most recently from Volz and colleagues. However, there is no current data available evaluating a role of tDCS for patients with chronic neuropathic pain treated with regional anaesthesiological techniques.
Objective: To evaluate effect of additional tDCS series on pain in patients with chronic neuropathic pain
Primary study endpoint: relative reduction in pain (initial VAS measured versus VAS after completion of the therapy series) as a numeric value between 0 and 10.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Control
sham transcranial direct current stimulation (tDCS)
sham transcranial direct current stimulation (tDCS)
transcranial direct current stimulation (tDCS) is applied in active groups using a sham-stimulation including ramp up and ramp down of current.
cathodal stimulation
cathodal transcranial direct current stimulation (tDCS)
cathodal transcranial direct current stimulation (tDCS)
transcranial direct current stimulation (tDCS) is applied in active groups using cathodal active M1 stimulation. Active stimulation is applied with 2mA direct current via 20cm² electrodes.
anodal stimulation
anodal transcranial direct current stimulation (tDCS)
anodal transcranial direct current stimulation (tDCS)
transcranial direct current stimulation (tDCS) is applied in active groups using anodal active M1 stimulation. Active stimulation is applied with 2mA direct current via 20cm² electrodes.
Interventions
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cathodal transcranial direct current stimulation (tDCS)
transcranial direct current stimulation (tDCS) is applied in active groups using cathodal active M1 stimulation. Active stimulation is applied with 2mA direct current via 20cm² electrodes.
sham transcranial direct current stimulation (tDCS)
transcranial direct current stimulation (tDCS) is applied in active groups using a sham-stimulation including ramp up and ramp down of current.
anodal transcranial direct current stimulation (tDCS)
transcranial direct current stimulation (tDCS) is applied in active groups using anodal active M1 stimulation. Active stimulation is applied with 2mA direct current via 20cm² electrodes.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Pregnancy
* Police custody
* Epilepsy
* Participation in another prospective clinical intervention study within the last 30 days
18 Years
ALL
No
Sponsors
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Charite University, Berlin, Germany
OTHER
Responsible Party
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Sascha Tafelski
physician scientist
Principal Investigators
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Michael Schäfer, Prof. MD
Role: STUDY_CHAIR
Charité University Berlin
Locations
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Pain Clinic of Charité hospital Campus Virchow Klinikum
Berlin, , Germany
Countries
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References
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Tafelski S, Beutlhauser T, Gouliou-Mayerhauser E, Fritzsche T, Denke C, Schafer M. [Practice of regional anesthesia for chronic pain patients in specialized pain services : A nationwide survey in Germany]. Schmerz. 2015 Apr;29(2):186-94. doi: 10.1007/s00482-014-1503-6. German.
Flor H, Nikolajsen L, Staehelin Jensen T. Phantom limb pain: a case of maladaptive CNS plasticity? Nat Rev Neurosci. 2006 Nov;7(11):873-81. doi: 10.1038/nrn1991.
Hauser W, Schmutzer G, Hinz A, Hilbert A, Brahler E. [Prevalence of chronic pain in Germany. A representative survey of the general population]. Schmerz. 2013 Feb;27(1):46-55. doi: 10.1007/s00482-012-1280-z. German.
Antal A, Terney D, Kuhnl S, Paulus W. Anodal transcranial direct current stimulation of the motor cortex ameliorates chronic pain and reduces short intracortical inhibition. J Pain Symptom Manage. 2010 May;39(5):890-903. doi: 10.1016/j.jpainsymman.2009.09.023.
Volz MS, Farmer A, Siegmund B. Reduction of chronic abdominal pain in patients with inflammatory bowel disease through transcranial direct current stimulation: a randomized controlled trial. Pain. 2016 Feb;157(2):429-437. doi: 10.1097/j.pain.0000000000000386.
Study Documents
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Document Type: Clinical Study Report
The research report is published open access: ORIGINAL RESEARCH article Front. Neurol., 01 March 2023, Volume 14 - 2023 \| https://doi.org/10.3389/fneur.2023.1069434
View DocumentRelated Links
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Pain Clinic Website
Other Identifiers
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Neuro-tDCS1
Identifier Type: -
Identifier Source: org_study_id
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