Influence of tDCS on Cortical Plasticity in Patients With Dementia of the Alzheimer Type

NCT ID: NCT01887899

Last Updated: 2021-05-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2013-05-31

Study Completion Date

2017-12-31

Brief Summary

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The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in patients with dementia of the Alzheimer type (DAT) leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).

Detailed Description

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Conditions

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Dementia of Type Alzheimer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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transcranial direct current stimulation

Group Type EXPERIMENTAL

transcranial direct current stimulation

Intervention Type DEVICE

sham stimulation

Group Type PLACEBO_COMPARATOR

sham stimulation

Intervention Type DEVICE

Interventions

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transcranial direct current stimulation

Intervention Type DEVICE

sham stimulation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Right-handed according to the Oldfield Händigkeits inventory (lateralization index\> 70) (1971)
* Cognitive impairment, which corresponds to a mild to moderate DAT
* No treatment with AChE inhibitors, or existing stable treatment with AChE inhibitors for over 3 months
* No motor impairments relevant to everyday life
* Age 50 to 80 years
* Existing Insurance certificate
* Existing informed consent

Exclusion Criteria

* Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
* Epilepsy, epileptic seizure in medical history
* Cognitive deficit (MMSE \<20)
* Depressive episode (Beck Depression Inventory (BDI)\> 12)
* intake of centrally active drugs \<3 months, particularly acetylcholinesterase inhibitors
* Pregnancy
* Pacemaker (contraindication for MRI)
* Other metal parts in the body (contraindication for MRI)
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Responsible Party

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Agnes Flöel

Prof. Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Klinik und Poliklinik für Neurologie, Charité Universitätsmedizin Berlin

Berlin, , Germany

Site Status

Countries

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Germany

Other Identifiers

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Plasticity in Alzheimer's

Identifier Type: -

Identifier Source: org_study_id

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