Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes
NCT ID: NCT01593956
Last Updated: 2013-05-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2012-03-31
Brief Summary
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GABAergic acitivty can be modulated by transcranial direct current stimulation (tDCS) in a polar-specific manner: anodal tDCS was able to decrease GABA, whereas cathodal tDCS increased tDCS.
Our study aimes to assess the influence of anodal tDCS on cortical plsticity in concussed athlethes. We hypothesize, that anodal tDCS is able to increase cortical plsticity in concussed athlethes.
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Detailed Description
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Conditions
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Study Design
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TREATMENT
Study Groups
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Concussed athletes
tDCS
Healthy controls
tDCS
Interventions
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tDCS
Eligibility Criteria
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Inclusion Criteria
* age 18 - 50 years
Exclusion Criteria
* Epilepsy
* neurological disorder
* intake of CNS-active drugs
18 Years
50 Years
ALL
Yes
Sponsors
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Charite University, Berlin, Germany
OTHER
Responsible Party
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Jonathan List
MD
Principal Investigators
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Jonathan List, MD
Role: PRINCIPAL_INVESTIGATOR
Charité - Department of Neurology
Agnes Flöel, Prof.
Role: PRINCIPAL_INVESTIGATOR
Charité - Department of Neurology
Locations
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Charité - Department of neurology
Berlin, , Germany
Countries
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Facility Contacts
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References
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De Beaumont L, Tremblay S, Poirier J, Lassonde M, Theoret H. Altered bidirectional plasticity and reduced implicit motor learning in concussed athletes. Cereb Cortex. 2012 Jan;22(1):112-21. doi: 10.1093/cercor/bhr096. Epub 2011 May 13.
Stagg CJ, Bachtiar V, Johansen-Berg H. The role of GABA in human motor learning. Curr Biol. 2011 Mar 22;21(6):480-4. doi: 10.1016/j.cub.2011.01.069. Epub 2011 Mar 3.
Stagg CJ, Best JG, Stephenson MC, O'Shea J, Wylezinska M, Kincses ZT, Morris PG, Matthews PM, Johansen-Berg H. Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation. J Neurosci. 2009 Apr 22;29(16):5202-6. doi: 10.1523/JNEUROSCI.4432-08.2009.
Other Identifiers
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EA1/021/12
Identifier Type: -
Identifier Source: org_study_id
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