Modulation of Motor Cortex Excitability by TMS and tDCS (MAGS1)
NCT ID: NCT03481309
Last Updated: 2021-03-04
Study Results
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View full resultsBasic Information
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COMPLETED
NA
19 participants
INTERVENTIONAL
2018-08-24
2019-02-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
QUADRUPLE
Study Groups
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anodal tDCS
Two electrodes will be applied to the scalp (one on the left motor cortex, one on the right supraorbital cortex). This anodal tDCS on the left motor cortex will be stimulated with 2mA for 10 minutes.
anodal tDCS
The participant will receive anodal tDCS with 2 mA for 10 minutes on the left motor cortex.
cathodal tDCS
Two electrodes will be applied to the scalp (one on the left motor cortex, one on the right supraorbital cortex). This cathodal tDCS on the left motor cortex will be stimulated with -2mA for 10 minutes.
cathodal tDCS
The participant will receive cathodal tDCS with -2 mA for 10 minutes on the left motor cortex.
sham tDCS
Two electrodes will be applied to the scalp (one on the left motor cortex, one on the right supraorbital cortex). Sham stimulation with 2mA for 40 seconds will be applied.
sham tDCS
The participant will receive sham tDCS with 2 mA for 40 seconds on the left motor cortex which mimics the skin sensations as active tDCS interventions.
Interventions
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anodal tDCS
The participant will receive anodal tDCS with 2 mA for 10 minutes on the left motor cortex.
cathodal tDCS
The participant will receive cathodal tDCS with -2 mA for 10 minutes on the left motor cortex.
sham tDCS
The participant will receive sham tDCS with 2 mA for 40 seconds on the left motor cortex which mimics the skin sensations as active tDCS interventions.
Eligibility Criteria
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Inclusion Criteria
* Between the ages of 18 and 35
* Right-handed
* Capacity to understand all relevant risks and potential benefits of the study (informed consent)
* Willing to comply with all study procedures and be available for the duration of the study
* Speak and understand English
Exclusion Criteria
* Diagnosis of eating disorder (current or within the past 6 months)
* Diagnosis of obsessive compulsive disorder (lifetime)
* Attention-deficit/hyperactivity disorder (currently under treatment)
* Neurological disorders and conditions, including, but not limited to:
* History of epilepsy
* Seizures (except childhood febrile seizures and electroconvulsive therapy-induced seizures)
* Dementia
* History of stroke
* Parkinson's disease
* Multiple sclerosis
* Cerebral aneurysm
* Brain tumors
* Medical or neurological illness or treatment for a medical disorder that could interfere with study participation (e.g., unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment)
* Prior brain surgery
* Any brain devices/implants, including cochlear implants and aneurysm clips
* Traumatic brain injury
* Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
18 Years
35 Years
MALE
Yes
Sponsors
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National Institute of Mental Health (NIMH)
NIH
University of North Carolina, Chapel Hill
OTHER
Responsible Party
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Principal Investigators
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Flavio Frohlich, PhD
Role: PRINCIPAL_INVESTIGATOR
University of North Carolina at Chapel Hill - Department of Psychiatry
Locations
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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17-0149
Identifier Type: -
Identifier Source: org_study_id
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