The Effect of Transcranial Direct Current Stimulation on Visual Attention - Single Sessions

NCT ID: NCT04134195

Last Updated: 2021-02-24

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-02-19
• Study Completion Date: 2020-12-30

Brief Summary

Recently, attention has been drawn to non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), in order to enhance cognitive functions by modifying brain plasticity and use it in different healthy and diseased populations. In the current research, investigator aim to examine the short-term effects of multiple tDCS protocols in healthy adults population on visual attention and identify the neural underpinnings of tDCS-induced behavioral aftereffects using a combined tDCS/ MRI network-based approach.

Detailed Description

Investigator will investigate the shor-term effects of active tDCS as compared to a placebo stimulation on visual attention in the healthy seniors. A cross-over, randomized, placebo-controlled design will be used. Single tDCS sessions will be performed in 4 sessions over distinct brain areas with ongoing visual attention training. During the stimulation, investigator will use the visual matching task. MRI protocol consisting of T1 and resting state fMRI sequences will be acquired before and after every stimulation session in order to search for active vs. placebo tDCS-induced changes in brain activation and resting state functional connectivity and to identify neural correlates of behavioral changes.

Conditions

Healthy Aging; Cognitive Change; Cognitive Decline

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: QUADRUPLE

Study Groups

Real transcranial direct current stimulation

Healthy adults and healthy seniors will undergo application of real transcranial direct current stimulation over two distinct brain areas.

Group Type: EXPERIMENTAL

Transcranial direct current stimulation

Intervention Type: DEVICE

2mA stimulation for 20 minutes

Sham transcranial direct current stimulation

Healthy adults and healthy seniors will undergo application of sham transcranial direct current stimulation over two distinct brain areas.

Group Type: EXPERIMENTAL

Transcranial direct current stimulation

Intervention Type: DEVICE

2mA stimulation for 20 minutes

Interventions

Transcranial direct current stimulation

2mA stimulation for 20 minutes

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• right handed, healthy volunteers in two groups - healthy adults under 40 years, healthy seniors over 50 years

Exclusion Criteria

• psychiatric disorders, including major depression, major vascular lesions, and other brain pathologies detected by MRI that might present with cognitive decline

• a cardio pacemaker or any MRI-incompatible metal in the body
• epilepsy
• any diagnosed psychiatric disorder
• alcohol/drug abuse
• lack of cooperation
• presence of cognitive impairment

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

St. Anne's University Hospital Brno, Czech Republic

OTHER

Sponsor Role: collaborator

Masaryk University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ľubomira Nováková

Role: PRINCIPAL_INVESTIGATOR

Ceitec, Masaryk University

Locations

Ceitec, Masaryk University

Brno, , Czechia

Countries

Czechia

Other Identifiers

NV18-04-00256-single

Identifier Type: -

Identifier Source: org_study_id