The Effect of Transcranial Direct Current Stimulation on Motor Performance in Healthy Adults

NCT ID: NCT04577768

Last Updated: 2020-10-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-07-11

Study Completion Date

2020-02-10

Brief Summary

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to investigate the effect of stimulation intensity on motor performance in healthy adults.

Detailed Description

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60 healthy subjects were randomly allocated to one of three groups: (a) 20-min of High-Definition transcranial direct current stimulation (HD-tDCS) with an intensity of 2 mA (HD-tDCS 2 mA); (2) 20-min of HD-tDCS with an intensity of 1.5 mA (HD-tDCS 1.5 mA); and (3) 20-min of sham HD-tDCS (HD-tDCS sham). The stimulation was administered noninvasively using an M x N 9-channel high definition transcranial electrical current stimulator from Soterix Medical (New York, NY). The anodal stimulation targeted the right Brodmann area 4 (primary motor cortex) based on HD-Targets brain modelling software (Soterix Medical, New York, NY).

Tests: The non-dominant left arm was tested. The subjects performed a sequential point-to-point movement task on the graphics tablet. Initially, the participants were required to perform 3 sequences without errors to familiarize themselves with the setup, the task and the sequence. Then, they performed the pre-test which consisted of two blocks of 6 sequences, i.e. 12 sequences, with a 30 s break between blocks. Two min after starting the appropriate stimulation, they performed 2 blocks of 6 sequences (identical to the pre-test). After finishing the tDCS stimulation, the participants performed a post-test, which was also identical to the pre-test. The participants returned after 24 hours to perform a retention test, which was equivalent to the pre- and post-tests. Two outcome measures were used: movement time (s) and the reaction time (s) of the reaching movements.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

randomized controlled trial (RCT)
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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HD-tDCS 2 mA

Single session of 20-min HD-tDCS to the right primary motor cortex with an intensity of 2 mA. The session lasted approximately one hour. The participants returned after 24 hours to perform a retention test.

Group Type EXPERIMENTAL

HD-tDCS 2 mA

Intervention Type DEVICE

anodal high definition transcranial direct current stimulation of the right primary motor cortex with an intensity of 2 mA

HD-tDCS 1.5 mA

Single session of 20-min HD-tDCS to the right primary motor cortex with an intensity of 1.5 mA. The session lasted approximately one hour. The participants returned after 24 hours to perform a retention test.

Group Type EXPERIMENTAL

HD-tDCS 1.5 mA

Intervention Type DEVICE

anodal high definition transcranial direct current stimulation of the right primary motor cortex with an intensity of 1.5 mA

Control

Single session of 20-min of sham HD-tDCS. The session lasted approximately one hour. The participants returned after 24 hours to perform a retention test.

Group Type SHAM_COMPARATOR

HD-tDCS sham

Intervention Type DEVICE

sham stimulation of the right primary motor cortex

Interventions

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HD-tDCS 2 mA

anodal high definition transcranial direct current stimulation of the right primary motor cortex with an intensity of 2 mA

Intervention Type DEVICE

HD-tDCS 1.5 mA

anodal high definition transcranial direct current stimulation of the right primary motor cortex with an intensity of 1.5 mA

Intervention Type DEVICE

HD-tDCS sham

sham stimulation of the right primary motor cortex

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* aged between 20 and 35
* right-hand dominant
* healthy according to self report

Exclusion Criteria

* taking psychiatric medications
* a history of drug abuse or dependence
* psychiatric or neurological disorder
* a history of seizures
* metal implants in their head
* musculoskeletal deficits interfering with task performance (proper reaching performance in sitting)
Minimum Eligible Age

20 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tel Aviv University

OTHER

Sponsor Role collaborator

Ariel University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Silvi Frenkel-Toledo

Role: PRINCIPAL_INVESTIGATOR

Ariel University

Locations

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Ariel University

Ariel, , Israel

Site Status

Countries

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Israel

References

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Lerner O, Friedman J, Frenkel-Toledo S. The effect of high-definition transcranial direct current stimulation intensity on motor performance in healthy adults: a randomized controlled trial. J Neuroeng Rehabil. 2021 Jun 26;18(1):103. doi: 10.1186/s12984-021-00899-z.

Reference Type DERIVED
PMID: 34174914 (View on PubMed)

Other Identifiers

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AU-HEA-SFT-20190326

Identifier Type: -

Identifier Source: org_study_id

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