Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals
NCT ID: NCT07026760
Last Updated: 2025-06-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE1
18 participants
INTERVENTIONAL
2022-10-01
2025-10-30
Brief Summary
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Detailed Description
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Methods: The study is a crossover, double-blind trial in which healthy adults (aged 18-40 years) undergo pre- and post-intervention assessments of cortical excitability (MEP, ICI, and ICF). Statistical analyses will be performed using ANOVA or Friedman tests (SPSS v.26).
The results will clarify whether the neuromodulatory effects of the stimulation are parameter-dependent and will guide future rehabilitation protocols for neurological conditions.
The research was approved by the Ethics Committee of the Federal University of Pernambuco (Resolution 466/12). All data will be stored securely for the next five years.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Trans-spinal magnetic stimulation (1 Hz + 90% MT)
Trans-spinal magnetic stimulation (90% MT + 1 Hz)
Low frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (1 Hz + 100% MT)
Trans-spinal magnetic stimulation (100% MT + 1 Hz)
Low frequency stimulation (1 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (1 Hz + 110% MT)
Trans-spinal magnetic stimulation (110% MT + 1 Hz)
Low frequency stimulation (1 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (10 Hz + 90% MT)
Trans-spinal magnetic stimulation (90% + 10 Hz)
High frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (10 Hz + 100% MT)
Trans-spinal magnetic stimulation (100% MT + 10 Hz)
High frequency stimulation (10 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (10 Hz + 110% MT)
Trans-spinal magnetic stimulation (110% MT + 10 Hz)
High frequency stimulation (10 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (25 Hz + 90% MT)
Trans-spinal magnetic stimulation (90% MT + 25 Hz)
High frequency stimulation (25 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (25 Hz + 100% MT)
Trans-spinal magnetic stimulation (100% MT + 25 Hz)
High frequency stimulation (25 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (25 Hz + 110% MT)
Trans-spinal magnetic stimulation (110% MT + 25 Hz)
High frequency stimulation (25 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.
Interventions
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Trans-spinal magnetic stimulation (90% MT + 1 Hz)
Low frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (100% MT + 1 Hz)
Low frequency stimulation (1 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (110% MT + 1 Hz)
Low frequency stimulation (1 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (90% + 10 Hz)
High frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (100% MT + 10 Hz)
High frequency stimulation (10 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (110% MT + 10 Hz)
High frequency stimulation (10 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (90% MT + 25 Hz)
High frequency stimulation (25 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (100% MT + 25 Hz)
High frequency stimulation (25 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.
Trans-spinal magnetic stimulation (110% MT + 25 Hz)
High frequency stimulation (25 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.
Eligibility Criteria
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Exclusion Criteria
18 Years
40 Years
ALL
Yes
Sponsors
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Universidade Federal de Pernambuco
OTHER
Responsible Party
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Kátia Monte-Silva
Professor
Locations
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Universidade Federal de Pernambuco
Recife, Pernambuco, Brazil
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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58678222.8.0000.5208
Identifier Type: -
Identifier Source: org_study_id
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