Cortical Dynamics of Inhibitory Control: A Concurrent tDCS-MEG Study
NCT ID: NCT03484377
Last Updated: 2020-02-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
36 participants
INTERVENTIONAL
2018-09-15
2019-02-28
Brief Summary
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Detailed Description
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The research hypotheses are that (i) a generalised mechanism for top-down inhibitory control will play a vital role, whereby prefrontal beta-band activity initiates alpha-band activity for functional inhibition over the frontal eye fields and other areas in the neurocircuitry involved in RRI; (ii) anodal tDCS (as opposed to sham) delivered over the right DLPFC will enhance this mechanism; and (iii) there will be no significant correlations between measures of self-report impulsivity and performance on the anti-saccade task and measures of oscillatory activity.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Anodal tDCS
The anodal tDCS electrode will be placed over the area corresponding to the right DLPFC (F4 of the EEG10-20 international system). The anodal tDCS condition will use a constant current of 2mA, delivered via gradual increase and decrease over 10 seconds at the onset and offset of stimulation (current ramps), respectively.
Anodal tDCS
The experimental condition will use a constant current of 2mA for 20 minutes, delivered via gradual increase and decrease over 10 seconds at the onset and offset of stimulation (current ramps), respectively.
Sham tDCS
The sham (cathodal) electrode will be placed over the left supraorbital ridge. The current will be delivered only in the first 10 seconds, after which the stimulation will cease but with the electrodes still in place throughout the session.
Sham tDCS
The anodal electrode will be placed over the supreorbital ridge. The current will be delivered only in the first 10 seconds, after which the stimulation will cease but with the electrodes still in place throughout the session. The session will last for 20 minutes.
Interventions
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Anodal tDCS
The experimental condition will use a constant current of 2mA for 20 minutes, delivered via gradual increase and decrease over 10 seconds at the onset and offset of stimulation (current ramps), respectively.
Sham tDCS
The anodal electrode will be placed over the supreorbital ridge. The current will be delivered only in the first 10 seconds, after which the stimulation will cease but with the electrodes still in place throughout the session. The session will last for 20 minutes.
Eligibility Criteria
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Inclusion Criteria
* Aged 18-40
Exclusion Criteria
* Contraindications to use of Magnetic Resonance (pacemakers, metal implants, aneurysm clips)
* Pregnancy.
18 Years
40 Years
ALL
Yes
Sponsors
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Medical Research Council
OTHER_GOV
University of Nottingham
OTHER
Najat Khalifa
OTHER_GOV
Responsible Party
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Najat Khalifa
Associate Professor
Principal Investigators
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Najat Khalifa, DM
Role: PRINCIPAL_INVESTIGATOR
University of Nottingham
Locations
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University of Nottingham
Nottingham, Notts, United Kingdom
Countries
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Provided Documents
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Document Type: Study Protocol
Other Identifiers
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199-1801
Identifier Type: OTHER
Identifier Source: secondary_id
CiC2017051
Identifier Type: -
Identifier Source: org_study_id
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